Petr Broz

Molecular mechanisms of inflammasome activation during microbial infections.

The needle length of bacterial injectisomes is determined by a molecular ruler.

Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes.

The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.

YscU recognizes translocators as export substrates of the Yersinia injectisome.

Function and molecular architecture of the Yersinia injectisome tip complex.

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.

Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing.

Innate immune recognition of francisella tularensis: activation of type-I interferons and the inflammasome.

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis.

Innate immune response to Salmonella typhimurium, a model enteric pathogen.

Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection.

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.

A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.

Newly described pattern recognition receptors team up against intracellular pathogens.

Measuring inflammasome activation in response to bacterial infection.

Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

Getting rid of the bad apple: inflammasome-induced extrusion of Salmonella-infected enterocytes.

Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux.