Matthew Merritt

Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.

Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.

PARACEST agents: modulating MRI contrast via water proton exchange.

Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding.

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.

Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.

Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.

Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.

Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.

A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications.

Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.

Adiabatic JHSQC for 13C isotopomer analysis.

Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane.

Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.

Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide.

Benefits of perfusion preservation in canine hearts stored for short intervals.

Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.

Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate.

Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.

Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism.

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment.

Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.

Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.

Hyperpolarized 89Y complexes as pH sensitive NMR probes.

Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.

The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate.

1H magic angle spinning magnetic resonance spectroscopy for monitoring machine-perfused canine donor heart preservation prior to transplantation.

DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.

Could 13C MRI assist clinical decision-making for patients with heart disease?

Glucose is an ineffective substrate for preservation of machine perfused donor hearts.

BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.

Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8.

Production and NMR characterization of hyperpolarized (107,109)Ag complexes.

Differences in regional myocardial perfusion, metabolism, MVO2, and edema after coronary sinus machine perfusion preservation of canine hearts.

Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.

Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.

Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.

Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.

The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy.

Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.

Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization.

Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.

Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.

Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion.

Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.

Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.

Propionate stimulates pyruvate oxidation in the presence of acetate.

Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.

Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.

Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.

Production of hyperpolarized (13)CO2 from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Metabolism of hyperpolarized [1-(13) C]pyruvate through alternate pathways in rat liver.

Multiband spectral-spatial RF excitation for hyperpolarized [2-(13) C]dihydroxyacetone (13) C-MR metabolism studies.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.