Ming-Yu Ngai

Highly enantioselective direct reductive coupling of conjugated alkynes and alpha-ketoesters via rhodium-catalyzed asymmetric hydrogenation.

Iridium-catalyzed C-C bond forming hydrogenation: direct regioselective reductive coupling of alkyl-substituted alkynes to activated ketones.

Hydrogen-mediated C-C bond formation: a broad new concept in catalytic C-C coupling.

Allylic amines via iridium-catalyzed C-C bond forming hydrogenation: imine vinylation in the absence of stoichiometric byproducts or metallic reagents.

Enantiomerically enriched allylic alcohols and allylic amines via C-C bond-forming hydrogenation: asymmetric carbonyl and imine vinylation.

Enantioselective iridium-catalyzed imine vinylation: optically enriched allylic amines via alkyne-imine reductive coupling mediated by hydrogen.

Enantioselective iridium-catalyzed carbonyl allylation from the alcohol or aldehyde oxidation level using allyl acetate as an allyl metal surrogate.

Ruthenium catalyzed C-C bond formation via transfer hydrogenation: branch-selective reductive coupling of allenes to paraformaldehyde and higher aldehydes.

Enantioselective iridium-catalyzed carbonyl allylation from the alcohol or aldehyde oxidation level via transfer hydrogenative coupling of allyl acetate: departure from chirally modified allyl metal reagents in carbonyl addition.

Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents.

Pd-catalyzed aryl C-H imidation with arene as the limiting reagent.

Trifluoromethoxylation of arenes: synthesis of ortho-trifluoromethoxylated aniline derivatives by OCF3 migration.

A Highly Convergent Total Synthesis of Leustroducsin B.