Susanne Schiffmann

Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.

DNA: a programmable force sensor.

Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.

Double-chip protein arrays: force-based multiplex sandwich immunoassays with increased specificity.

Double chip protein arrays using recombinant single-chain Fv antibody fragments.

Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.

In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin.

Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.

p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells.

Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

Dimethylcelecoxib inhibits prostaglandin E2 production.

The anti-proliferative potency of celecoxib is not a class effect of coxibs.

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis.

Ceramide synthases and ceramide levels are increased in breast cancer tissue.

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.

Cellular membranes function as a storage compartment for celecoxib.

Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide.

Inhibitors of specific ceramide synthases.

Chain length-specific properties of ceramides.

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.

The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.

Ceramide metabolism in mouse tissue.

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture.

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.