Charles C. Hong

Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling.

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells.

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification.

BMP type I receptor inhibition reduces heterotopic [corrected] ossification.

Large-scale small-molecule screen using zebrafish embryos.

Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.

Applications of small molecule BMP inhibitors in physiology and disease.

In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.

Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva.

Serial observations and mutational analysis of an adoptee with family history of hypertrophic cardiomyopathy.

sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair.

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.

Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling.

Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.

The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.

Regenerative chemical biology: current challenges and future potential.

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Multi-step usage of in vivo models during rational drug design and discovery.

Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors.

Familial evaluation for diagnosis of arrhythmogenic right ventricular dysplasia.

Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.

Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation.

BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion.