Bart Spee

Detection of Helicobacter pylori in bile of cats.

The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns.

Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers.

Quantitative PCR method to detect a 13-kb deletion in the MURR1 gene associated with copper toxicosis and HIV-1 replication.

Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment.

Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies.

Development and evaluation of canine reference genes for accurate quantification of gene expression.

Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin.

Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs.

Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis.

Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells.

In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor.

Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin.

In vitro differentiation of liver progenitor cells derived from healthy dog livers.

The dog liver contains a "side population" of cells with hepatic progenitor-like characteristics.

A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis.

Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease.

Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling.

Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours.

Recombinant hepatocyte growth factor treatment in a canine model of congenital liver hypoplasia.

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.

Aberrant gene expression in dogs with portosystemic shunts.

Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs.

Safety and efficacy field study of artesunate for dogs with non-resectable tumours.

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas.

Classification of primary hepatic tumours in the dog.

Potential of regenerative medicine techniques in canine hepatology.

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.

Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies.

Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs.

Classification of primary hepatic tumours in the cat.

Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells.

Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche.

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow.

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.

ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.

Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.