Sabine Gerbal-Chaloin

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.

Use of long-term cultures of human hepatocytes to study cytochrome P450 gene expression.

Pathophysiological factors affecting CAR gene expression.

Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids.

Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation.

Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

First step of the cell-penetrating peptide mechanism involves Rac1 GTPase-dependent actin-network remodelling.

Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.

Human pluripotent stem cells: from biology to cell therapy.

Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal.

Dissecting the first transcriptional divergence during human embryonic development.

Nuclear receptors in the cross-talk of drug metabolism and inflammation.

Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes.

Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy.

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.

PBPK modeling of irbesartan: incorporation of hepatic uptake.

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.