Ying Qing Yu

Enzyme-friendly, mass spectrometry-compatible surfactant for in-solution enzymatic digestion of proteins.

A rapid sample preparation method for mass spectrometric characterization of N-linked glycans.

Identification of N-linked glycosylation sites using glycoprotein digestion with pronase prior to MALDI tandem time-of-flight mass spectrometry.

Mixed-mode chromatography for fractionation of peptides, phosphopeptides, and sialylated glycopeptides.

Phosphopeptide enrichment using microscale titanium dioxide solid phase extraction.

Separation of 2-aminobenzamide labeled glycans using hydrophilic interaction chromatography columns packed with 1.7 microm sorbent.

Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies.

Ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) and UPLC/MS(E) analysis of RNA oligonucleotides.

Characterization of glycoprotein digests with hydrophilic interaction chromatography and mass spectrometry.

Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation.

Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi.

Accessing the reproducibility and specificity of pepsin and other aspartic proteases.

Characterisation of glycoproteins using a quadrupole time-of-flight mass spectrometer configured for electron transfer dissociation.

N- and O-glycosylation analysis of etanercept using liquid chromatography and quadrupole time-of-flight mass spectrometry equipped with electron-transfer dissociation functionality.

Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques.

In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate.

Glycan characterization of the NIST RM monoclonal antibody using a total analytical solution: From sample preparation to data analysis.