Tomoki Chiba

Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.

Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.

E3 ubiquitin ligase that recognizes sugar chains.

Conditional knockdown of proteasomes results in cell-cycle arrest and enhanced expression of molecular chaperones Hsp70 and Hsp40 in chicken DT40 cells.

CHIP: a quality-control E3 ligase collaborating with molecular chaperones.

A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes.

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.

Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein.

The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress.

Structural basis of sugar-recognizing ubiquitin ligase.

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.

Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system.

Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradation.

Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.

Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.

DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice.

Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.

Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.

[Biology of the reversible protein ubiquitination].

14-3-3eta is a novel regulator of parkin ubiquitin ligase.

In vitro systems for NEDD8 conjugation by Ubc12.

Excess peroxisomes are degraded by autophagic machinery in mammals.

[Regulation of the protein degradation pathway by the ubiquitin family: its implication in neurodegenerative diseases].

The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1.

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells.

Depletion of hsp90beta induces multiple defects in B cell receptor signaling.

Loss of autophagy in the central nervous system causes neurodegeneration in mice.

Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity.

[NEDD8 conjugation system].

[Physiological role in constitutive autophagy].

Decline of striatal dopamine release in parkin-deficient mice shown by ex vivo autoradiography.

SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.

Isolation and characterization of phage-displayed single chain antibodies recognizing nonreducing terminal mannose residues. 1. A new strategy for generation of anti-carbohydrate antibodies.

Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity.

TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation.

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.

SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

Allele-selective effect of PA28 in MHC class I antigen processing.

A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation.

Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing.

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

The mechanism of poly-NEDD8 chain formation in vitro.

Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells.

Bioluminescence assay for detecting cell surface membrane protein expression.

[Recognition of CD1d/glycolipid antigen complex by NKT cells and mechanisms in immune regulation].

Interplay of transcription factors in T-cell differentiation and function: the role of Runx.

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.

Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.

Cell activation by CpG ODN leads to improved electrofusion in hybridoma production.

IκBL, a novel member of the nuclear IκB family, inhibits inflammatory cytokine expression.

Smad7-deficient mice show growth retardation with reduced viability.

Guidelines for the use and interpretation of assays for monitoring autophagy.

A method for inducing antigen-specific IgG production by in vitro immunization.

Reciprocal control of G1-phase progression is required for Th-POK/Runx3-mediated CD4/8 thymocyte cell fate decision.

Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice.

Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly.

Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.

Brap2 regulates temporal control of NF-κB localization mediated by inflammatory response.

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.

Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus.

Role of nuclear IκBs in inflammation regulation.

TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis.

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.

KIAA0368-deficiency affects disassembly of 26S proteasome under oxidative stress condition.

Proteasome activators, PA28γ and PA200, play indispensable roles in male fertility.

SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression.

CACUL1/CAC1 attenuates p53 activity through PML post-translational modification.

Structural Changes in Molluscan Community over a 15-Year Period before and after the 2011 Great East Japan Earthquake and Subsequent Tsunami around Matsushima Bay, Miyagi Prefecture, Northeastern Japan.

Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.