George A. O'Toole

Microbiology: a resistance switch.

Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1.

To build a biofilm.

Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms.

Transition from reversible to irreversible attachment during biofilm formation by Pseudomonas fluorescens WCS365 requires an ABC transporter and a large secreted protein.

A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance.

Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14.

SadB is required for the transition from reversible to irreversible attachment during biofilm formation by Pseudomonas aeruginosa PA14.

Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli.

Microbiology: Jekyll or hide?

Evidence for two flagellar stators and their role in the motility of Pseudomonas aeruginosa.

A three-component regulatory system regulates biofilm maturation and type III secretion in Pseudomonas aeruginosa.

Susceptibility of biofilms to Bdellovibrio bacteriovorus attack.

Heparin stimulates Staphylococcus aureus biofilm formation.

Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms.

Pseudomonas aeruginosa inhibits endocytic recycling of CFTR in polarized human airway epithelial cells.

Biofilms strike back.

Conservation of the Pho regulon in Pseudomonas fluorescens Pf0-1.

Biofilm formation by Pseudomonas fluorescens WCS365: a role for LapD.

Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces.

Saccharomyces cerevisiae-based molecular tool kit for manipulation of genes from gram-negative bacteria.

Peptide-PEG amphiphiles as cytophobic coatings for mammalian and bacterial cells.

Vulnerability of pathogenic biofilms to Micavibrio aeruginosavorus.

Bacterial biofilms and ocular infections.

Phosphate-dependent modulation of c-di-GMP levels regulates Pseudomonas fluorescens Pf0-1 biofilm formation by controlling secretion of the adhesin LapA.

Inverse regulation of biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

The Pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulator.

Roles for flagellar stators in biofilm formation by Pseudomonas aeruginosa.

BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.

SadC reciprocally influences biofilm formation and swarming motility via modulation of exopolysaccharide production and flagellar function.

The flagellum of Pseudomonas aeruginosa is required for resistance to clearance by surfactant protein A.

In vivo growth of Pseudomonas aeruginosa strains PAO1 and PA14 and the hypervirulent strain LESB58 in a rat model of chronic lung infection.

In vitro analysis of tobramycin-treated Pseudomonas aeruginosa biofilms on cystic fibrosis-derived airway epithelial cells.

Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway.

Genetic evidence for an alternative citrate-dependent biofilm formation pathway in Staphylococcus aureus that is dependent on fibronectin binding proteins and the GraRS two-component regulatory system.

The DeltaF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability.

Cif is negatively regulated by the TetR family repressor CifR.

Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif.

Growing and analyzing static biofilms.

Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa.

The developmental model of microbial biofilms: ten years of a paradigm up for review.

Tobramycin and FDA-approved iron chelators eliminate Pseudomonas aeruginosa biofilms on cystic fibrosis cells.

LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1.

Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles.

New yeast recombineering tools for bacteria.

Directed assembly of PEGylated-peptide coatings for infection-resistant titanium metal.

Flagellum-mediated biofilm defense mechanisms of Pseudomonas aeruginosa against host-derived lactoferrin.

The Pseudomonas aeruginosa magnesium transporter MgtE inhibits transcription of the type III secretion system.

Sugar fatty acid esters inhibit biofilm formation by food-borne pathogenic bacteria.

Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor.

Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways.

Cyclic-di-GMP-mediated repression of swarming motility by Pseudomonas aeruginosa: the pilY1 gene and its impact on surface-associated behaviors.

Antibodies and immune effectors: shaping Gram-negative bacterial phenotypes.

Pseudomonas aeruginosa evasion of phagocytosis is mediated by loss of swimming motility and is independent of flagellum expression.

Staphylococcus aureus resistance on titanium coated with multivalent PEGylated-peptides.

Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases.

A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage.

Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis.

Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins.

Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide.

A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system.

Modulation of Pseudomonas aeruginosa surface-associated group behaviors by individual amino acids through c-di-GMP signaling.

Systematic analysis of diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0-1.

Step-wise loss of bacterial flagellar torsion confers progressive phagocytic evasion.

2-Heptyl-4-quinolone, a precursor of the Pseudomonas quinolone signal molecule, modulates swarming motility in Pseudomonas aeruginosa.

Exploiting Dendrimer Multivalency To Combat Emerging and Re-Emerging Infectious Diseases.

Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa.

Diphosphonium Ionic Liquids as Broad-Spectrum Antimicrobial Agents.

Structural characterization of a conserved, calcium-dependent periplasmic protease from Legionella pneumophila.

LapG, required for modulating biofilm formation by Pseudomonas fluorescens Pf0-1, is a calcium-dependent protease.

Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?

In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells.

Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa.

Iron homeostasis during cystic fibrosis pulmonary exacerbation.

The CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages.

Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems.

Atomic force and super-resolution microscopy support a role for LapA as a cell-surface biofilm adhesin of Pseudomonas fluorescens.

Cyclic-di-GMP signalling regulates motility and biofilm formation in Bordetella bronchiseptica.

Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination.

Pouring salt on a wound: Pseudomonas aeruginosa virulence factors alter Na+ and Cl- flux in the lung.

Iron supplementation does not worsen respiratory health or alter the sputum microbiome in cystic fibrosis.

Synthesis of Bioinspired Carbohydrate Amphiphiles that Promote and Inhibit Biofilms.

Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation.

Single-molecule analysis of Pseudomonas fluorescens footprints.

Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity.

Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment.

Single-cell and single-molecule analysis deciphers the localization, adhesion, and mechanics of the biofilm adhesin LapA.

Deletion mutant library for investigation of functional outputs of cyclic diguanylate metabolism in Pseudomonas aeruginosa PA14.

Micro-patterned surfaces reduce bacterial colonization and biofilm formation in vitro: Potential for enhancing endotracheal tube designs.

Plate-based assay for swimming motility in Pseudomonas aeruginosa.

Plate-based assay for swarming motility in Pseudomonas aeruginosa.

Structural features of the Pseudomonas fluorescens biofilm adhesin LapA required for LapG-dependent cleavage, biofilm formation, and cell surface localization.

The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.

The microbiome in pediatric cystic fibrosis patients: the role of shared environment suggests a window of intervention.

Epoxide-mediated differential packaging of Cif and other virulence factors into outer membrane vesicles.

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP.

Candida albicans ethanol stimulates Pseudomonas aeruginosa WspR-controlled biofilm formation as part of a cyclic relationship involving phenazines.

Surface attachment induces Pseudomonas aeruginosa virulence.

Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis.

A hierarchical cascade of second messengers regulates Pseudomonas aeruginosa surface behaviors.

Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis.

Coculture of Staphylococcus aureus with Pseudomonas aeruginosa Drives S. aureus towards Fermentative Metabolism and Reduced Viability in a Cystic Fibrosis Model.

Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes.

Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance.

Cyclic Di-GMP-Regulated Periplasmic Proteolysis of a Pseudomonas aeruginosa Type Vb Secretion System Substrate.

c-di-GMP and its Effects on Biofilm Formation and Dispersion: a Pseudomonas Aeruginosa Review.

Tobramycin-Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System.

Mannitol Does Not Enhance Tobramycin Killing of Pseudomonas aeruginosa in a Cystic Fibrosis Model System of Biofilm Formation.

Classic Spotlight: Before They Were Biofilms.

Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector.

Iron-dependent gene expression in Actinomyces oris.

Cystic Fibrosis Lung Infections: Polymicrobial, Complex, and Hard to Treat.

Classic Spotlight: Quorum Sensing and the Multicellular Life of Unicellular Organisms.

Species-dependent hydrodynamics of flagellum-tethered bacteria in early biofilm development.

Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems.

Sensational biofilms: surface sensing in bacteria.

The Inhibitory Site of a Diguanylate Cyclase Is a Necessary Element for Interaction and Signaling with an Effector Protein.

PilZ Domain Protein FlgZ Mediates Cyclic Di-GMP-Dependent Swarming Motility Control in Pseudomonas aeruginosa.

Classic Spotlight: Cyclic Di-GMP, the Molecule That Makes the Bacterial World Stop Going 'Round.

Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors.

Requirements for Pseudomonas aeruginosa Type I-F CRISPR-Cas Adaptation Determined Using a Biofilm Enrichment Assay.

Special Meeting Sections for the 7th ASM Conference on Biofilms.

Classic Spotlight: Bacteroides thetaiotaomicron, Starch Utilization, and the Birth of the Microbiome Era.

Classic Spotlight: Plate Counting You Can Count On.

Classic Spotlight: How the Gram Stain Works.

Role of Cyclic Di-GMP and Exopolysaccharide in Type IV Pilus Dynamics.

Bacteria, Rev Your Engines: Stator Dynamics Regulate Flagellar Motility.

Alginate Overproduction Promotes Coexistence with in a Model of Cystic Fibrosis Respiratory Infection.

Pseudomonas aeruginosa-Derived Rhamnolipids and Other Detergents Modulate Colony Morphotype and Motility in the Burkholderia cepacia Complex.

Special Meeting Sections.

Classic Spotlights: Selected Highlights from the First 100 Years of the .

A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling.

Special Meeting Sections for the 6th ASM Conference on Beneficial Microbes.

Alters Staphylococcus Sensitivity to Vancomycin in a Biofilm Model of Cystic Fibrosis Infection.

High-Speed "4D" Computational Microscopy of Bacterial Surface Motility.

An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.

Special Meeting Sections for the ASM Conference on Mechanisms of Interbacterial Cooperation and Competition.

Cystic Fibrosis Airway Microbiome: Overturning the Old, Opening the Way for the New.

A Multimodal Strategy Used by a Large c-di-GMP Network.

An N-Terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: a Novel Subfamily of Type I Secretion Systems.

Multigenerational memory and adaptive adhesion in early bacterial biofilm communities.

Type 1 Does the Two-Step: Type 1 Secretion Substrates with a Functional Periplasmic Intermediate.

Special Sections for the 6th ASM Conference on Cell-Cell Communication in Bacteria.

Ligand-Mediated Biofilm Formation via Enhanced Physical Interaction between a Diguanylate Cyclase and Its Receptor.

Co-opting the Lap System of Pseudomonas fluorescens To Reversibly Customize Bacterial Cell Surfaces.

Flagellar Stators Stimulate c-di-GMP Production by Pseudomonas aeruginosa.

Pseudomonas aeruginosa Can Inhibit Growth of Streptococcal Species via Siderophore Production.

The Yin and Yang of Lung Infections in Cystic Fibrosis: a Model for Studying Polymicrobial Interactions.

Gross transcriptomic analysis of Pseudomonas putida for diagnosing environmental shifts.

Metabolic Modeling of Cystic Fibrosis Airway Communities Predicts Mechanisms of Pathogen Dominance.

Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice.

Altered Stool Microbiota of Infants with Cystic Fibrosis Shows a Reduction in Genera Associated with Immune Programming from Birth.

Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics.

Special Meeting Issue for the 8th ASM Conference on Biofilms.

Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of Biofilms.

"It Takes a Village": Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms.

Lying in Wait: Modeling the Control of Bacterial Infections via Antibiotic-Induced Proviruses.

Availability of Zinc Impacts Interactions between Streptococcus sanguinis and Pseudomonas aeruginosa in Coculture.

Interspecies interactions induce exploratory motility in .

Exogenous Alginate Protects Staphylococcus aureus from Killing by Pseudomonas aeruginosa.

Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1.

Lung function and microbiota diversity in cystic fibrosis.

Age and environmental exposures influence the fecal bacteriome of young children with cystic fibrosis.

MapA, a Second Large RTX Adhesin Conserved across the Pseudomonads, Contributes to Biofilm Formation by Pseudomonas fluorescens.

Pseudomonas aeruginosa PA14 Enhances the Efficacy of Norfloxacin against Staphylococcus aureus Newman Biofilms.

From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.

Discovering the Molecular Determinants of Phaeobacter inhibens Susceptibility to Phaeobacter Phage MD18.

Aerosolized drug-loaded nanoparticles targeting migration inhibitory factors inhibit -induced inflammation and biofilm formation.

Identification of cell-surface glycans that mediate motility-dependent binding and internalization of Pseudomonas aeruginosa by phagocytes.

Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.

Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance.

Metabolic Modeling to Interrogate Microbial Disease: A Tale for Experimentalists.

Characterization of Ciprofloxacin Resistance Levels: Implications for Ototopical Therapy.

One versus Many: Polymicrobial Communities and the Cystic Fibrosis Airway.

Interaction between the type 4 pili machinery and a diguanylate cyclase fine-tune c-di-GMP levels during early biofilm formation.

Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability.

Biochemical and structural characterization of two cif-like epoxide hydrolases from .

The Gut-Lung Axis in Cystic Fibrosis.