Anna C. Hearps

HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.

Regulating the functions of the HIV-1 matrix protein.

The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells.

The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.

Evaluation of the blood stabilizers TransFix and Cyto-Chex BCT for low-cost CD4 T-cell methodologies.

Effect of reverse transcriptase inhibitors and mutations on the low-cost Cavidi reverse transcriptase viral load assay.

An HIV-1 integrase genotype assay for the detection of drug resistance mutations.

Stability of dried blood spots for HIV-1 drug resistance analysis.

An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import.

HIV infection and aging of the innate immune system.

HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy.

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.

Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation.

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Age-associated changes in monocyte and innate immune activation markers occur more rapidly in HIV infected women.

First molecular epidemiology study of Mycobacterium tuberculosis in Kiribati.

Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals.

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.

Acquisition of HIV by African-born residents of Victoria, Australia: insights from molecular epidemiology.

Inflammatory co-morbidities in HIV+ individuals: learning lessons from healthy ageing.

Presence of HIV drug resistance in antiretroviral therapy-naive and -experienced patients from Papua New Guinea.

The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure.

Viremic and Virologically Suppressed HIV Infection Increases Age-Related Changes to Monocyte Activation Equivalent to 12 and 4 Years of Aging, Respectively.

Inflammation-induced foam cell formation in chronic inflammatory disease.

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.

An NK Cell Population Lacking FcRγ Is Expanded in Chronically Infected HIV Patients.

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.

Monocytes from HIV-infected individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration.

Factors Influencing Antiretroviral Adherence and Virological Outcomes in People Living with HIV in the Highlands of Papua New Guinea.

Ex vivo foam cell formation is enhanced in monocytes from older individuals by both extrinsic and intrinsic mechanisms.

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

High Levels of Transmitted HIV Drug Resistance in a Study in Papua New Guinea.

Persistence of Activated and Adaptive-Like NK Cells in HIV(+) Individuals despite 2 Years of Suppressive Combination Antiretroviral Therapy.

Dysfunctional HDL from HIV+ individuals promotes monocyte-derived foam cell formation in vitro.