Lonnie D. Shea

Tissue-engineered follicles produce live, fertile offspring.

Gene expression and internalization following vector adsorption to immobilized proteins: dependence on protein identity and density.

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models.

Drug-releasing scaffolds fabricated from drug-loaded microspheres.

Surface-tethered DNA complexes for enhanced gene delivery.

Controllable delivery of non-viral DNA from porous scaffolds.

Murine granulosa cell morphology and function are regulated by a synthetic Arg-Gly-Asp matrix.

Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification.

Novel approach for the three-dimensional culture of granulosa cell-oocyte complexes.

Controlled release systems for DNA delivery.

Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern.

Modular design of non-viral vectors with bioactive components.

Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface.

DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach.

Gene delivery through cell culture substrate adsorbed DNA complexes.

Neurotrophin releasing single and multiple lumen nerve conduits.

Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection.

Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose.

The in vitro regulation of ovarian follicle development using alginate-extracellular matrix gels.

Design of modular non-viral gene therapy vectors.

Gene delivery from polymer scaffolds for tissue engineering.

Nerve growth factor expression by PLG-mediated lipofection.

Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery.

Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression.

Cancer survivors and infertility: a review of a new problem and novel answers.

Substrate-mediated delivery from self-assembled monolayers: effect of surface ionization, hydrophilicity, and patterning.

Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis.

Inductive tissue engineering with protein and DNA-releasing scaffolds.

Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility.

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation.

Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool.

Extracellular matrix functions in follicle maturation.

Identification of a stage-specific permissive in vitro culture environment for follicle growth and oocyte development.

Back to the science of stem cell research - CHI's 2nd Annual Meeting.

The structures that underlie normal reproductive function.

Spatially patterned gene delivery for localized neuron survival and neurite extension.

Patterned PLG substrates for localized DNA delivery and directed neurite extension.

Bioluminescence imaging for assessment and normalization in transfected cell arrays.

Matrices and scaffolds for DNA delivery in tissue engineering.

Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism.

Non-viral vector delivery from PEG-hyaluronic acid hydrogels.

Engineering the follicle microenvironment.

Physical properties of alginate hydrogels and their effects on in vitro follicle development.

Surface polyethylene glycol enhances substrate-mediated gene delivery by nonspecifically immobilized complexes.

Bioengineering and the ovarian follicle.

The role of the extracellular matrix in ovarian follicle development.

Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion.

Peptide-mediated lipofection is governed by lipoplex physical properties and the density of surface-displayed amines.

Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma.

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation.

Layered PLG scaffolds for in vivo plasmid delivery.

Spatially patterned gene expression for guided neurite extension.

Self-assembling peptide-lipoplexes for substrate-mediated gene delivery.

The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.

Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury.

Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury.

Efficacy of immobilized polyplexes and lipoplexes for substrate-mediated gene delivery.

Secondary follicle growth and oocyte maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles.

Sustained transgene expression via citric acid-based polyester elastomers.

Fibrin hydrogels for non-viral vector delivery in vitro.

Preserving female fertility following cancer treatment: current options and future possibilities.

Non-viral gene delivery transfection profiles influence neuronal architecture in an in vitro co-culture model.

Gene Delivery by Immobilization to Cell-Adhesive Substrates.

Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

Multiple channel bridges for spinal cord injury: cellular characterization of host response.

Encapsulated three-dimensional culture supports development of nonhuman primate secondary follicles.

In vitro grown human ovarian follicles from cancer patients support oocyte growth.

Interpenetrating fibrin-alginate matrices for in vitro ovarian follicle development.

Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model.

Engineering surfaces for substrate-mediated gene delivery using recombinant proteins.

Lentivirus delivery by adsorption to tissue engineering scaffolds.

The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds.

A novel two-step strategy for in vitro culture of early-stage ovarian follicles in the mouse.

Lentivirus immobilization to nanoparticles for enhanced and localized delivery from hydrogels.

Markers of growth and development in primate primordial follicles are preserved after slow cryopreservation.

Patterned transgene expression in multiple-channel bridges after spinal cord injury.

Noninvasive index of cryorecovery and growth potential for human follicles in vitro.

Phosphatidylserine immobilization of lentivirus for localized gene transfer.

Balancing cell migration with matrix degradation enhances gene delivery to cells cultured three-dimensionally within hydrogels.

Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma.

Designing follicle-environment interactions with biomaterials.

To transplant or not to transplant - that is the question.

Cellular arrays for large-scale analysis of transcription factor activity.

A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health.

Dynamic, large-scale profiling of transcription factor activity from live cells in 3D culture.

In vitro oocyte maturation and preantral follicle culture from the luteal-phase baboon ovary produce mature oocytes.

Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture.

Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.

Gene therapy vectors with enhanced transfection based on hydrogels modified with affinity peptides.

Gene expression in mouse ovarian follicle development in vivo versus an ex vivo alginate culture system.

Engineering biomaterial systems to enhance viral vector gene delivery.

Vascular endothelial growth factor and fibroblast growth factor 2 delivery from spinal cord bridges to enhance angiogenesis following injury.

Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice.

Fibrin hydrogels for lentiviral gene delivery in vitro and in vivo.

Tissue engineering tools for modulation of the immune response.

Hydrogel design for supporting neurite outgrowth and promoting gene delivery to maximize neurite extension.

Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury.

Hydrogels to modulate lentivirus delivery in vivo from microporous tissue engineering scaffolds.

Embryonic fibroblasts enable the culture of primary ovarian follicles within alginate hydrogels.