David W.H. Riches

Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domain.

Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis.

Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13.

Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis.

TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.

Peroxisome proliferator-active receptor gamma: a legitimate target to control pulmonary inflammation?

Differential regulation of TNF-R1 signaling: lipid raft dependency of p42mapk/erk2 activation, but not NF-kappaB activation.

IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal.

Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis.

Transcription of macrophage IGF-I exon 1 is positively regulated by the 5'-untranslated region and negatively regulated by the 5'-flanking region.

Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites.

ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking.

TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis.

Regulation of chemokine expression by NaCl occurs independently of cystic fibrosis transmembrane conductance regulator in macrophages.

TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1.

Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Introduction and perspective.

Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.

Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.

Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis.

Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways.

Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice.

TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.

Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.

PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.

TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface.

Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner.

Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis.

Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.

Lung dendritic cells at the innate-adaptive immune interface.

Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis.

A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice.

Spatiotemporal Inhibition of Innate Immunity Signaling by the Tbc1d23 RAB-GAP.