normothermic-ex-situ-heart-perfusion-working-mode-assessment-cardiac

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

The current standard method for organ preservation (cold storage, CS), exposes the heart to a period of cold ischemia that limits the safe preservation ...

University of Alberta

Conventional ion-selective electrodes with a liquid junction have the disadvantage of potential drift. All-solid-state ion-selective electrodes with solid contact in between the metal electrode and the ion-selective membrane offer high capacitance or conductance to enhance potential stability. Solution-casted chitosan/Prussian blue nanocomposite (ChPBN) was employed as the solid contact layer for an all-solid-state sodium ion-selective electrode in a potentiometric sodium ion sensor. Morphological and chemical analyses confirmed that the ChPBN is a macroporous network of chitosan that contains abundant Prussian blue nanoparticles. Situated between a screen-printed carbon electrode and a sodium-ionophore-filled polyvinylchloride ion-selective membrane, the ChPBN layer exhibited high redox capacitance and fast charge transfer capability, which significantly enhanced the performance of the sodium ion-selective electrode. A good Nernstian response with a slope of 52.4 mV/decade in the linear range from 10-1 M of NaCl was observed. The stability of the electrical potential of the new solid contact was tested by chronopotentiometry, and the capacitance of the electrode was 154 ± 4 µF. The response stability in terms of potential drift was excellent (1.3 µV/h) for 20 h of continuous measurement. The ChPBN proved to be an efficient solid contact to enhance the potential stability of the all-solid-state ion-selective electrode.

All-Solid-State Sodium-Selective Electrode with a Solid Contact of Chitosan/Prussian Blue Nanocomposite.

Wearable healthcare systems require skin-adhering electrodes that allow maximal comfort for patients as well as an electronics system to enable signal processing and transmittance. Textile-based electronics, known as "e-textiles," is a platform technology that allows comfort for patients. Here, two-layered e-textile patches are designed by controlled permeation of Ag-particle/fluoropolymer composite ink into a porous textile. The permeated ink forms a cladding onto the nanofibers in the textile substrate, which is beneficial for mechanical and electrical properties of the e-textile. The printed e-textile features conductivity of ≈3200 S cm , whereas 1000 cycles of 30% uniaxial stretching causes the resistance to increase only by a factor of ≈5, which is acceptable in many applications. Controlling over the penetration depth enables a two-layer design of the e-textile, where the sensing electrodes and the conducting traces are printed in the opposite sides of the substrate. The formation of vertical interconnected access is remarkably simple as an injection from a syringe. With the custom-developed electronic circuits, a surface electromyography system with wireless data transmission is demonstrated. Furthermore, the dry e-textile patch collects electroencephalography with comparable signal quality to commercial gel electrodes. It is anticipated that the two-layered e-textiles will be effective in healthcare and sports applications.

Two-Layered and Stretchable e-Textile Patches for Wearable Healthcare Electronics.

Polyampholyte hydrogels (PAHs) constitute a class of physical gels with cross-linking originating from inter- and intrachain ionic cross-linking between countercharged functional groups. In our previous report, we have shown that PAH has the potential to be a gel electrolyte in electrochemical energy storage devices. In this work, we further our understanding of charge-balanced PAH as a host material for gel electrolytes by studying the effect of dialysis on the mechanical properties and ionic conductivities of PAHs, whereas these properties are compared with those of poly(vinyl alcohol) (PVA)-based gel electrolytes. Here, various electrolyte solutions were investigated as dialyzing agents. The ionic species in the electrolytes form ion pairs with countercharged functional groups in PAH, whereas such interactions govern the ionic conductivity and mechanical strength of PAH in various electrolytes. For anions, the trend in ionic interactions follows the Hofmeister series in an exact manner, whereas some anomaly is observed among cations. We anticipate that our study provides a design criterion for fabricating gel electrolytes. In a broader context, this work can shed light on understanding the behavior of PAHs in various operational environments, such as under physiological conditions and in antifouling coatings for biomedical and maritime applications, respectively.

Hyun-Joong Chung

Department of Chemical and Materials Engineering,
Faculty of Engineering,
Department of Chemical and Materials Engineering, Faculty of Engineering

University of Alberta

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Hyun-Joong Chung

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Chemical and Materials Engineering,Faculty of Engineering,Department of Chemical and Materials Engineering, Faculty of Engineering

University of Alberta

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Department of Chemical and Materials Engineering,
Faculty of Engineering,
Department of Chemical and Materials Engineering, Faculty of Engineering