David M. Langenau

Myc-induced T cell leukemia in transgenic zebrafish.

Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.

The use of zebrafish to understand immunity.

In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish.

Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation.

Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

The zebrafish: a new model of T-cell and thymic development.

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.

Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish.

Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish.

Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters.

Construction and application of a zebrafish array comparative genomic hybridization platform.

Zebrafish as a model for cancer self-renewal.

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia.

aMAZe-ing tools for mosaic analysis in zebrafish.

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA).

High-throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.

Zebrafish models of rhabdomyosarcoma.

Fluorescent imaging of cancer in zebrafish.

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.

In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.

Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs).

Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish.

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.

The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish.

Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis.

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.

Pten regulates zebrafish hematopoiesis.

Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation.

Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.

Zebrafish as a model to assess cancer heterogeneity, progression and relapse.

Lineage of origin in rhabdomyosarcoma informs pharmacological response.

Optimized cell transplantation using adult rag2 mutant zebrafish.

Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies.