Hideki Hasegawa

Protection against influenza virus infection by nasal vaccination in advance of sublethal irradiation.

Persistent infection of influenza virus in irradiated mice and its prevention by intranasal vaccination.

Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines.

Topoisomerase I and ATP activate cDNA synthesis of human immunodeficiency virus type 1.

Reconstitution of cleavage of human immunodeficiency virus type-1 (HIV-1) RNAs.

Binding and dissociation of human topoisomerase I with hairpin-loop RNAs: implications for the regulation of HIV-1 replication.

Processing of the HTLV-II envelope precursor glycoprotein gp63 by furin is essential for cell fusion activity.

Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB.

Roles of anti-hemagglutinin IgA and IgG antibodies in different sites of the respiratory tract of vaccinated mice in preventing lethal influenza pneumonia.

Human topoisomerase I promotes HIV-1 proviral DNA synthesis: implications for the species specificity and cellular tropism of HIV-1 infection.

Cross-reactive antigenicity of nucleoproteins of lyssaviruses recognized by a monospecific antirabies virus nucleoprotein antiserum on paraffin sections of formalin-fixed tissues.

Protection against influenza virus infection by intranasal administration of C3d-fused hemagglutinin.

Topoisomerase I dissociates human immunodeficiency virus type 1 reverse transcriptase from genomic RNAs.

Nucleolin and the packaging signal, psi, promote the budding of human immunodeficiency virus type-1 (HIV-1).

BCL-6-positive human herpesvirus 8-associated solid lymphoma arising from liver and spleen as multiple nodular lesions.

Differential localization of neurons susceptible to enterovirus 71 and poliovirus type 1 in the central nervous system of cynomolgus monkeys after intravenous inoculation.

Protection against influenza virus infection by intranasal administration of hemagglutinin vaccine with chitin microparticles as an adjuvant.

Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection.

Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus.

An attenuated LC16m8 smallpox vaccine: analysis of full-genome sequence and induction of immune protection.

Dicer and positive charge of proteins decrease the stability of RNA containing the AU-rich element of GM-CSF.

Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I.

Distribution of PrP(Sc) in cattle with bovine spongiform encephalopathy slaughtered at abattoirs in Japan.

Induction of protective immunity against severe acute respiratory syndrome coronavirus (SARS-CoV) infection using highly attenuated recombinant vaccinia virus DIs.

LC16m8, a highly attenuated vaccinia virus vaccine lacking expression of the membrane protein B5R, protects monkeys from monkeypox.

Protection against influenza virus infection by intranasal vaccine with surf clam microparticles (SMP) as an adjuvant.

Tristetraprolin inhibits HIV-1 production by binding to genomic RNA.

Intranasal administration of adjuvant-combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection.

Pathological and virological analyses of severe acute respiratory syndrome-associated coronavirus infections in experimental animals.

Highly attenuated vaccinia virus DIs as a potential SARS vaccine.

Participation of both host and virus factors in induction of severe acute respiratory syndrome (SARS) in F344 rats infected with SARS coronavirus.

Development of a mucosal vaccine for influenza viruses: preparation for a potential influenza pandemic.

Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus.

Intranasal immunization with H5N1 vaccine plus Poly I:Poly C12U, a Toll-like receptor agonist, protects mice against homologous and heterologous virus challenge.

Cross-protection against H5N1 influenza virus infection is afforded by intranasal inoculation with seasonal trivalent inactivated influenza vaccine.

Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes.

Diagnosis and assessment of monkeypox virus (MPXV) infection by quantitative PCR assay: differentiation of Congo Basin and West African MPXV strains.

Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice.

Innate sensors of influenza virus: clues to developing better intranasal vaccines.

Monoclonal antibody and siRNAs for topoisomerase I suppress telomerase activity.

Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model.

Comparison of acellular pertussis-based combination vaccines by Japanese control tests for toxicities and laboratory models for local reaction.

Loop-mediated isothermal amplification-based diagnostic assay for monkeypox virus infections.

Protective immunity afforded by inactivated H5N1 (NIBRG-14) vaccine requires antibodies against both hemagglutinin and neuraminidase in mice.

Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses.

Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates.

Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma.

Rabies virus dissemination in neural tissues of autopsy cases due to rabies imported into Japan from the Philippines: immunohistochemistry.

Effects of the number of amino acid residues in the signal segment upstream or downstream of the NS2B-3 cleavage site on production and secretion of prM/M-E virus-like particles of West Nile virus.

PolyI:polyC12U adjuvant-combined intranasal vaccine protects mice against highly pathogenic H5N1 influenza virus variants.

Covalent bonded Gag multimers in human immunodeficiency virus type-1 particles.

Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia.

Estimation of the effective doses of nasal-inactivated influenza vaccine in humans from mouse-model experiments.

The first autopsy case of pandemic influenza (A/H1N1pdm) virus infection in Japan: detection of a high copy number of the virus in type II alveolar epithelial cells by pathological and virological examination.

An outbreak of histoplasmosis among healthy young Japanese women after traveling to Southeast Asia.

Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates.

Characterization of quasispecies of pandemic 2009 influenza A virus (A/H1N1/2009) by de novo sequencing using a next-generation DNA sequencer.

Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus.

Identification and molecular characterization of a new nonsegmented double-stranded RNA virus isolated from Culex mosquitoes in Japan.

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia.

Cross-protective immunity against influenza virus infections induced by intranasal vaccination together with a TLR3-mucosal adjuvant.

Mobile and accurate detection system for infection by the 2009 pandemic influenza A (H1N1) virus with a pocket-warmer reverse-transcriptase loop-mediated isothermal amplification.

Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection.

Pathology of Kaposi's Sarcoma-Associated Herpesvirus Infection.

A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase.

Outer membrane vesicles of Porphyromonas gingivalis elicit a mucosal immune response.

Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine.

Herpes simplex virus 1 VP22 regulates translocation of multiple viral and cellular proteins and promotes neurovirulence.

Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in burmese rhesus macaques.

Mucosal IgA responses in influenza virus infections; thoughts for vaccine design.

Identification of a varicella-zoster virus replication inhibitor that blocks capsid assembly by interacting with the floor domain of the major capsid protein.

Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease.

Lethal canine distemper virus outbreak in cynomolgus monkeys in Japan in 2008.

Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam.

Frequent detection of Merkel cell polyomavirus DNA in sera of HIV-1-positive patients.

Evaluation of the effectiveness and safety of chitosan derivatives as adjuvants for intranasal vaccines.

Canine distemper virus associated with a lethal outbreak in monkeys can readily adapt to use human receptors.

Characterization of H7N9 influenza A viruses isolated from humans.

Excessive cytokine response to rapid proliferation of highly pathogenic avian influenza viruses leads to fatal systemic capillary leakage in chickens.

Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3.

Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition.

The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.

Neutrophil depletion suppresses pulmonary vascular hyperpermeability and occurrence of pulmonary edema caused by hantavirus infection in C.B-17 SCID mice.

The prevalence of opportunistic infections and malignancies in autopsied patients with human immunodeficiency virus infection in Japan.

Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine.

Combatting infectious diseases; nanotechnology as a platform for rational vaccine design.

Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential.

Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.

Mucosal immunization and adjuvants.

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma.

Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkey.

Detection of trichodysplasia spinulosa-associated polyomavirus in a fatal case of myocarditis in a seven-month-old girl.

Evidence for human herpesvirus-6B infection of regulatory T-cells in acute systemic lymphadenitis in an immunocompetent adult with the drug reaction with eosinophilia and systemic symptoms syndrome: a case report.

Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections.

The pathogenesis of 3 neurotropic flaviviruses in a mouse model depends on the route of neuroinvasion after viremia.

A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.

Seroprevalence of trichodysplasia spinulosa-associated polyomavirus in Japan.

Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.

Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan.

Fumagillin, a potent angiogenesis inhibitor, induces Kaposi sarcoma-associated herpesvirus replication in primary effusion lymphoma cells.

Protective antibody responses against A(H1N1)pdm09 primed by infection and recalled by intranasal vaccination.

The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine.

Development of a new real-time PCR system for simultaneous detection of bacteria and fungi in pathological samples.

Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models.

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion.

Adenovirus Type 7 Pneumonia in Children Who Died from Measles-Associated Pneumonia, Hanoi, Vietnam, 2014.

Arenavirus Diversity and Phylogeography of Mastomys natalensis Rodents, Nigeria.

Non Susceptibility of Neonatal and Adult Rats against the Middle East Respiratory Syndrome Coronavirus.

Severe Fever with Thrombocytopenia Syndrome Virus Antigen Detection Using Monoclonal Antibodies to the Nucleocapsid Protein.

Evaluation of Vero-cell-derived simian endogenous retrovirus infection in humans by detection of viral genome in clinicopathological samples and commercialized vaccines and by serology of Japanese general population.

Intranasal Inactivated Influenza Vaccines: a Reasonable Approach to Improve the Efficacy of Influenza Vaccine?

Efficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome Virus.

Histopathological Findings of Lung with A/H1N1pdm09 Infection-Associated Acute Respiratory Distress Syndrome in the Post-Pandemic Season.

TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.

Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model.

Assessment of outer membrane vesicles of periodontopathic bacterium Porphyromonas gingivalis as possible mucosal immunogen.

Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System.

Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi's sarcoma-associated herpesvirus.

Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.

Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines.

Deep-Sequence Identification and Role in Virus Replication of a JC Virus Quasispecies in Patients with Progressive Multifocal Leukoencephalopathy.

Protective neutralizing influenza antibody response in the absence of T follicular helper cells.

The Microminipig as an Animal Model for Influenza A Virus Infection.

Reducing the global burden of HTLV-1 infection: An agenda for research and action.

A Single Vaccination of Nonhuman Primates with Highly Attenuated Smallpox Vaccine, LC16m8, Provides Long-term Protection against Monkeypox.

Screening transplant donors for HTLV-1 and -2.

Unusual presentation of a severely ill patient having severe fever with thrombocytopenia syndrome: a case report.

Next-generation sequencing of miRNAs in clinical samples of Epstein-Barr virus-associated B-cell lymphomas.

Impacts of allergic airway inflammation on lung pathology in a mouse model of influenza A virus infection.

2016 International meeting of the Global Virus Network.

Intranasal Administration of Whole Inactivated Influenza Virus Vaccine as a Promising Influenza Vaccine Candidate.

Conserved sequences of BART and BHRF regions encoding viral microRNAs in Epstein-Barr virus-associated lymphoma.

Functional and structural characteristics of secretory IgA antibodies elicited by mucosal vaccines against influenza virus.

Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection.

Interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets.

The road to a more effective influenza vaccine: Up to date studies and future prospects.

Emergence of Oseltamivir-Resistant H7N9 Influenza Viruses in Immunosuppressed Cynomolgus Macaques.

A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets.

Induction of lung CD8 T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine.

Alleviation of lipopolysaccharide/d-galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice.

A patient with severe fever with thrombocytopenia syndrome and hemophagocytic lymphohistiocytosis-associated involvement of the central nervous system.

Combination Therapy With Neuraminidase and Polymerase Inhibitors in Nude Mice Infected With Influenza Virus.

Syrian Hamster as an Animal Model for the Study of Human Influenza Virus Infection.

cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue.

Characterization of a Feline Influenza A(H7N2) Virus.

Mechanism of Action of the Anti-Influenza Virus Active Kampo (Traditional Japanese Herbal) Medicine, Hochuekkito.

Neutralizing Antibodies Induced by Gene-Based Hydrodynamic Injection Have a Therapeutic Effect in Lethal Influenza Infection.

2017 international meeting of the Global Virus Network.

IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration.

Experimental infection of Cynomolgus Macaques with highly pathogenic H5N1 influenza virus through the aerosol route.

Application of HTLV-1 tax transgenic mice for therapeutic intervention.

A Sialylated Voltage-Dependent Ca Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells.

The Marmoset as an Animal Model of Influenza: Infection With A(H1N1)pdm09 and Highly Pathogenic A(H5N1) Viruses via the Conventional or Tracheal Spray Route.

Intranasal inactivated influenza vaccines for the prevention of seasonal influenza epidemics.

Mouse LIMR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils.

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody.

Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus.

TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection.

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

Transient Appearance of Plasmablasts in the Peripheral Blood of Japanese Patients with Severe Fever with Thrombocytopenia Syndrome.