Daniel J. Tschumperlin

Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.

Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.

Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation.

Mechanotransduction through growth-factor shedding into the extracellular space.

EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in.

Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.

Chronic effects of mechanical force on airways.

Computational modeling of extracellular mechanotransduction.

Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.

A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels.

Universal physical responses to stretch in the living cell.

Chronic intermittent mechanical stress increases MUC5AC protein expression.

Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases.

Recent advances and new opportunities in lung mechanobiology.

An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.

The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression.

Matrix rigidity regulates cancer cell growth and cellular phenotype.

TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.

A 3-D model of ligand transport in a deforming extracellular space.

Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Physical forces and airway remodeling in asthma.

A multiwell platform for studying stiffness-dependent cell biology.