David Scadden

Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.

Human HTm4 is a hematopoietic cell cycle regulator.

Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma.

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells.

Thymocyte emigration is mediated by active movement away from stroma-derived factors.

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy.

Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.

Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors.

Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma.

The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization.

Heterologous cells cooperate to augment stem cell migration, homing, and engraftment.

Toward cellular-based therapies for HIV infection.

The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation.

Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects.

Lack of antitumor activity and intolerance of interleukin-4 in patients with advanced HIV disease and Kaposi's sarcoma.

AIDS-related malignancies.

The level of MEF but not ELF-1 correlates with FAB subtype of acute myeloid leukemia and is low in good prognosis cases.

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells.

Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter.

P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.

Immune reconstitution in HIV infection and its relationship to cancer.

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels.

Stem cells and immune reconstitution in AIDS.

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

The malignant side of successful transplantation.

P21cip1/waf1 受限制的缺血性脑的再生反应。

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment.

Cancer stem cells refined.

Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function.

Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.

Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team.

The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.

Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management.

Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa.

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation.

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010.

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells.

Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.

Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.

Interview with David Scadden. Interview by Joseph Glorioso and Jenny Jacoby.

Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.

Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.

HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency.

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.

Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm.

Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.

Nervous activity in a stem cell niche.

CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus.

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.

The hematopoietic stem cell in its place.

Stem cells: good, bad and reformable.

Osteoclasts eat stem cells out of house and home.

The stem-cell niche as an entity of action.

Embryonic stem cells make human T cells.

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.

Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy.

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro.

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Therapeutic targeting of a stem cell niche.

Primitive hematopoietic cells resist HIV-1 infection via p21.

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

The stem cell niche in health and leukemic disease.

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.

Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma.

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.

The weight of cell identity.

Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020.

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.

Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.

Prospects for stem cell-based therapy.

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.

Circadian rhythms: stem cells traffic in time.

Flow electroporation with pulsed electric fields for purging tumor cells.

Stem cells remember their grade.

Limiting factors in murine hematopoietic stem cell assays.

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Stem-cell ecology and stem cells in motion.

Differentiation and characterization of T cells.

Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.

Differential H3K4 methylation identifies developmentally poised hematopoietic genes.

Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.

Evolving concepts on the microenvironmental niche for hematopoietic stem cells.

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.

Analysis of the hematopoietic stem cell niche.

GATA-2 regulates granulocyte-macrophage progenitor cell function.

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

Divided within: heterogeneity within adult stem cell pools.

Will stem cells finally deliver?

Forward RNAi screens in primary human hematopoietic stem/progenitor cells.

Role of the osteoblast lineage in the bone marrow hematopoietic niches.

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.

p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.

The leukemic stem cell niche: current concepts and therapeutic opportunities.

VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).

CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

The HSC niche concept has turned 31. Has our knowledge matured?

MicroRNA miR-125a controls hematopoietic stem cell number.

Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen.

Stem cells and DNA damage: persist or perish?

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.

Defining the hematopoietic stem cell niche.

A microRNA regulating adult hematopoietic stem cells.

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.

Adult stem cels and their niches.

Biomimetic platforms for human stem cell research.

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.

Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

Differential niche and Wnt requirements during acute myeloid leukemia progression.

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Diabetes impairs hematopoietic stem cell mobilization by altering niche function.

NF-Y is necessary for hematopoietic stem cell proliferation and survival.

The haematopoietic stem cell niche at a glance.

The bone marrow at the crossroads of blood and immunity.

The hematopoietic stem cell niche.

Advancing Stem Cell Biology toward Stem Cell Therapeutics.

Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-associated Kaposi sarcoma in South Africa.

Deconstructing the complexity of a microenvironmental niche.

The secrets of the bone marrow niche: Metabolic priming for AML.

Rethinking stroma: lessons from the blood.

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.

The stem cell niche: tissue physiology at a single cell level.

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.

Fate through fat: lipid metabolism determines stem cell division outcome.

Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop.

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.

The hematopoietic stem cell niche--home for friend and foe?

In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

SIRT3 reverses aging-associated degeneration.

Xist RNA is a potent suppressor of hematologic cancer in mice.

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

Differential stem- and progenitor-cell trafficking by prostaglandin E2.

Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.

Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Differential regulation of myeloid leukemias by the bone marrow microenvironment.

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

Modeling human hematopoietic stem cell biology in the mouse.

Blood scent.

Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.

The bone marrow niche for haematopoietic stem cells.

Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Bone's dark side: mutated osteoblasts implicated in leukemia.

Direct measurement of local oxygen concentration in the bone marrow of live animals.

Nice neighborhood: emerging concepts of the stem cell niche.

Tic-TACs: Refreshing Hair Growth.

Bayesian approach to single-cell differential expression analysis.

Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.

SnapShot: The hematopoietic stem cell niche.

Blood loses it when nerves go bad.

D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL.

Deep diving in the blood stem cell-ome.

Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.

Cellular thrust and parry in the leukemic niche.

Ischemic stroke activates hematopoietic bone marrow stem cells.

Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.

From quiescence to senescence.

Bone marrow stem cells: current and emerging concepts.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

Mesenchymal Cell Contributions to the Stem Cell Niche.

Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.