Robert B. Clarke

A putative human breast stem cell population is enriched for steroid receptor-positive cells.

Do early premalignant changes in normal breast epithelial cells predict cancer development?

Stem cells and tissue homeostasis in mammary glands.

Human breast epithelial stem cells and their regulation.

Isolation and characterization of human mammary stem cells.

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions.

Ovarian steroids and the human breast: regulation of stem cells and cell proliferation.

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

Estrogen deprivation for breast cancer prevention.

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.

Origins of breast cancer subtypes and therapeutic implications.

Mammary stem cells and breast cancer--role of Notch signalling.

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer.

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.

The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis.

Are stem-like cells responsible for resistance to therapy in breast cancer?

Resistance to endocrine therapy: are breast cancer stem cells the culprits?

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen.

Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

It's all in the details: methods in breast development and cancer.

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells.

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.

Breast cancer stem cells: something out of notching?

Breast cancer stem cells and their role in resistance to endocrine therapy.

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.

The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts.

Stem cells in breast tumours: are they ready for the clinic?

A detailed mammosphere assay protocol for the quantification of breast stem cell activity.

Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.

Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status.

Combining Notch inhibition with current therapies for breast cancer treatment.

Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling.

Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.

Wnt pathway activity in breast cancer sub-types and stem-like cells.

Targeting IL-8 signalling to inhibit breast cancer stem cell activity.

Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.

‘The charmingest place’: non-coding RNA, lineage tracing, tumor heterogeneity, metastasis and metabolism--new methods in mammary gland development and cancer: the fifth ENBDC Workshop.

Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity.

P-cadherin signals through the laminin receptor α6β4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells.

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.

17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells.

Patient-derived xenograft models: an emerging platform for translational cancer research.

Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy.

Co-ordination of cell cycle, migration and stem cell-like activity in breast cancer.

Risk determination and prevention of breast cancer.

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells.

The seventh ENBDC workshop on methods in mammary gland development and cancer.

The role of steroid hormones in breast cancer stem cells.

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation.

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.

Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.

Intermittent energy restriction induces changes in breast gene expression and systemic metabolism.

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop "Methods in Mammary Gland Development and Cancer".

Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts.

Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP.

Ethnicity influences breast cancer stem cells' drug resistance.

The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.

Hormones and cancer: update from Tokyo 2010.

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.

Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors.

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.

The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts.

The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling.

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling.

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts.

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH Breast Cancer Stem Cells.