Angela Santoni

Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells.

The chemokine growth-related gene product beta protects rat cerebellar granule cells from apoptotic cell death through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.

Polyclonal Antibodies Against gp185HER2 Peptides: Their Putative Role in the Identification of a Particular HER2 Status in Patients With Breast Cancer.

Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.

Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes.

Expansion of cytotoxic effectors with lytic activity against autologous blasts from acute myeloid leukaemia patients in complete haematological remission.

Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells.

Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.

SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells.

Analysis of the role of chemokines in angiogenesis.

Defective expression of the T-cell receptor-CD3 zeta chain in T-cell acute lymphoblastic leukaemia.

Memory T-cell competition for bone marrow seeding.

Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration.

The cyclopentenone-type prostaglandin 15-deoxy-delta 12,14-prostaglandin J2 inhibits CD95 ligand gene expression in T lymphocytes: interference with promoter activation via peroxisome proliferator-activated receptor-gamma-independent mechanisms.

Evaluation of Rho family small G-protein activity induced by integrin ligation on human leukocytes.

In vitro and in vivo models to study chemokine regulation of angiogenesis.

Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect.

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.

Hyperthermia enhances CD95-ligand gene expression in T lymphocytes.

Arf6: a new player in FcgammaRIIIA lymphocyte-mediated cytotoxicity.

Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling.

CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function.

High-efficient lentiviral vector-mediated gene transfer into primary human NK cells.

Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity.

Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines.

15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors.

Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.

Negative signals from FcepsilonRI engagement attenuate mast cell functions.

Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes.

The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway.

Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells.

Pathophysiology of ageing, longevity and age related diseases.

Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis.

Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy.

CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets.

Uterine NK cell development, migration and function.

Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy.

Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow.

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells.

Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors.

Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation.

Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.

Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state.

Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies.

CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-β1.

Ubiquitination and endocytosis of the high affinity receptor for IgE.

Chemokines and glioma: invasion and more.

Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease.

The cooperation between hMena overexpression and HER2 signalling in breast cancer.

CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.

DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction.

Cbl family proteins: balancing FcεRI-mediated mast cell and basophil activation.

Transcriptional modulation of a human monocytic cell line exposed to PM(10) from an urban area.

Ex vivo acidic preconditioning enhances bone marrow ckit+ cell therapeutic potential via increased CXCR4 expression.

PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway.

NKG2D/Ligand dysregulation and functional alteration of innate immunity cell populations in pediatric IBD.

The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR.

IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.

Chemokines and NK cells: regulators of development, trafficking and functions.

Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship.

Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FcεRI engagement: impact on Hrs membrane/cytosol localization.

Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy.

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses.

Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow.

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

Activation of Lymphocyte Cytolytic Machinery: Where are We?

Cancer-associated CD43 glycoforms as target of immunotherapy.

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma.

Multiple levels of chemokine receptor regulation in the control of mouse natural killer cell development.

Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells.

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1.

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91.

Regulation of fc receptor endocytic trafficking by ubiquitination.

NK cells and interferons.

Multifunctional human CD56 low CD16 low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients.

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice.

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients.

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions.

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma.

Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells.

The multifaceted role of PIP2 in leukocyte biology.

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma.

In Vivo Imaging of Natural Killer Cell Trafficking in Tumors.

Regulation and trafficking of the HLA-E molecules during monocyte-macrophage differentiation.

Response to comment on Multifunctional human CD56low CD16low NK cells are the prominent subset in bone marrow of both pediatric healthy donors and leukemic patients.

Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment.

The human antibody fragment DIATHIS1 specific for CEACAM1 enhances natural killer cell cytotoxicity against melanoma cell lines in vitro.

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells.

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells.

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies.

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression.

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer.

Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.

Regulation of NKG2D Expression and Signaling by Endocytosis.

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.

Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases.

NK cell effector functions in a Chédiak-Higashi patient undergoing cord blood transplantation: Effects of in vitro treatment with IL-2.

Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients.

Natural killer cell recognition of drug-induced senescent multiple myeloma cells.

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay.

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner.

CXCR3/CXCL10 Axis Regulates Neutrophil-NK Cell Cross-Talk Determining the Severity of Experimental Osteoarthritis.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.

GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells.

The Multifunctional Role of the Chemokine System in Arthritogenic Processes.

High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma.

Role of Distinct Natural Killer Cell Subsets in Anticancer Response.

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis.

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production.

Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells.

Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy.

Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis.

Multicolor flow cytometric analysis of TLR2 and TLR9 expression and function in NK cells from patients with ANCA-associated vasculitis.

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy.

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

Reconstitution of multifunctional CD56CD16 natural killer cell subset in children with acute leukemia given α/β T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation.

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance.

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.

Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial.

Environmental stimuli shape microglial plasticity in glioma.

Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties.

Chemokine regulation of innate lymphoid cell tissue distribution and function.

NCR ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.

Impact of bone marrow-derived signals on NK cell development and functional maturation.

NKG2D and Its Ligands: "One for All, All for One".

Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 -Presentation.

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.

Tumor-Targeting Anti-CD20 Antibodies Mediate Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and Priming.

Re: Gut Microbiome Influences Efficacy of PD-1-based Immunotherapy Against Epithelial Tumors.

hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.

"Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses.

Ca-activated K channels modulate microglia affecting motor neuron survival in hSOD1 mice.

The yin-yang of the interaction between myelomonocytic cells and NK cells.

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.

Translating the anti-myeloma activity of Natural Killer cells into clinical application.

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination.

Key Role of the CD56CD16 Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells.

Vaccines: An achievement of civilization, a human right, our health insurance for the future.

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response.

Negative regulation of innate lymphoid cell responses in inflammation and cancer.

Dendritic cells modulate c-kit expression on the edge between activation and death.

Senescent cells: Living or dying is a matter of NK cells.

Memory NK Cell Features Exploitable in Anticancer Immunotherapy.

The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing.

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors.

Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms.

The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress.

Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization.

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells.

Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells.

NK Cell Reconstitution in Paediatric Leukemic Patients after T-Cell-Depleted HLA-Haploidentical Haematopoietic Stem Cell Transplantation Followed by the Reinfusion of iCasp9-Modified Donor T Cells.

Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation.

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention.

Cancer extracellular vesicles as novel regulators of NK cell response.

Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer.

CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γ cytokine stimulation via PI3K/mTOR axis.

CD155: A Multi-Functional Molecule in Tumor Progression.

Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice.

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor.

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis.

Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses.

The ambiguity of opioids revealed by immunology is changing the knowledge and the therapeutic approach in cancer and non-cancer pain: A narrative review.

Neutrophil diversity and plasticity in tumour progression and therapy.

Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer.

FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes.

The global response to the COVID-19 pandemic: how have immunology societies contributed?

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.

Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer.

Immunology and Algology speak a common language - Editorial.

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells.

Chronic cancer and non cancer pain and opioid-induced hyperalgesia share common mechanisms: neuroinflammation and central sensitization.

Regulation of PD-L1 Expression by NF-κB in Cancer.

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases.