Bengt Winblad

The antidepressant and antiinflammatory effects of rolipram in the central nervous system.

Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment.

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.

Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study.

Piracetam: a review of pharmacological properties and clinical uses.

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings.

3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy.

Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study.

A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule.

Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease.

Occludin is overexpressed in Alzheimer's disease and vascular dementia.

IDEAL: a 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease.

Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study.

Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden.

The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium.

Therapeutic use of nicergoline.

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae.

Use of rivastigmine transdermal patch in the treatment of Alzheimer's disease.

Donepezil in severe Alzheimer's disease.

Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.

The rat as an animal model of Alzheimer's disease.

Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project.

Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.

Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease.

Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells.

Leisure activities in late life in relation to dementia risk: principal component analysis.

Atrial fibrillation, stroke and dementia in the very old: a population-based study.

Donepezil treatment in severe Alzheimer's disease: a pooled analysis of three clinical trials.

CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2.

Low diastolic pressure and risk of dementia in very old people: a longitudinal study.

Affinity pulldown of γ-secretase and associated proteins from human and rat brain.

Biomarkers for Alzheimer's disease and other forms of dementia: clinical needs, limitations and future aspects.

Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Synaptic and endosomal localization of active gamma-secretase in rat brain.

Vascular risk profiles for dementia and Alzheimer's disease in very old people: a population-based longitudinal study.

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology.

The worldwide societal costs of dementia: Estimates for 2009.

gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.

High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age.

Rethinking Alzheimer's disease therapy: are mitochondria the key?

Dimebon (latrepirdine) enhances mitochondrial function and protects neuronal cells from death.

Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer's disease and vascular dementia.

Alzheimer's disease: clinical trials and drug development.

Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study.

Association of Omi/HtrA2 with γ-secretase in mitochondria.

Accelerated progression from mild cognitive impairment to dementia in people with diabetes.

Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice?

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.

Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease.

HPA axis dysregulation associated to apolipoprotein E4 genotype in Alzheimer's disease.

Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation.

A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease.

Linkage to the 8p21.1 region Including the CLU gene in age at onset stratified alzheimer's disease families.

Phenserine efficacy in Alzheimer's disease.

Memantine benefits functional abilities in moderate to severe Alzheimer's disease.

The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study.

Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.

Morphological and behavioral changes induced by transgenic overexpression of interleukin-1ra in the brain.

Linkage analysis of autopsy-confirmed familial Alzheimer disease supports an Alzheimer disease locus in 8q24.

Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease.

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.

Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse.

Predictors of costs of care in Alzheimer's disease: a multinational sample of 1222 patients.

Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells.

Dementia management programme in a community setting and the use of psychotropic drugs in the elderly population.

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions.

Analysis of microdissected neurons by 18O mass spectrometry reveals altered protein expression in Alzheimer's disease.

Validation of the relevant outcome scale for Alzheimer's disease: a novel multidomain assessment for daily medical practice.

Depression in dementia: epidemiology, mechanisms, and treatment.

Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.

side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons.

Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.

A novel approach for Aβ₁₋₄₀ quantification using immuno-PCR.

Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.

Psychosocial stress at work is associated with increased dementia risk in late life.

Dementia diagnosis differs in men and women and depends on age and dementia severity: data from SveDem, the Swedish Dementia Quality Registry.

How can elderly apolipoprotein E ε4 carriers remain free from dementia?

Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing.

Practical lessons from amyloid immunotherapy trials in Alzheimer disease.

Cerebrospinal Fluid Alzheimer Markers in Depressed Elderly Subjects with and without Alzheimer's Disease.

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.

An active lifestyle postpones dementia onset by more than one year in very old adults.

Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.

Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain.

Mortality and treatment costs have a great impact on the cost-effectiveness of disease modifying treatment in Alzheimer's disease--a simulation study.

Application of Resource Utilization in Dementia (RUD) instrument in a global setting.

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers.

The worldwide economic impact of dementia 2010.

Abnormal platelet amyloid-β protein precursor (AβPP) metabolism in Alzheimer's disease: identification and characterization of a new AβPP isoform as potential biomarker.

The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease.

Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease.

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden.

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.

Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival.

The role of protein glycosylation in Alzheimer disease.

Corrigendum to Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers Neurobiology of Aging 63 (2018) 88-95.

Neuropathologic assessment of dementia markers in identical and fraternal twins.

Active immunotherapy options for Alzheimer's disease.

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

Vitamin D in relation to cognitive impairment, cerebrospinal fluid biomarkers, and brain volumes.

Long-term metformin usage and cognitive function among older adults with diabetes.

Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014.

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster.

mTor is a signaling hub in cell survival: a mass-spectrometry-based proteomics investigation.

The battle of Alzheimer's Disease - the beginning of the future Unleashing the potential of academic discoveries.

Cardiovascular medication burden in dementia disorders: a nationwide study of 19,743 dementia patients in the Swedish Dementia Registry.

Alzheimer and platelets: low-density platelet populations reveal increased serotonin content in Alzheimer type dementia.

Medial temporal lobe atrophy and depressive symptoms in elderly patients with and without Alzheimer disease.

Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.

Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects.

Erratum to: Cardiovascular medication burden in dementia disorders: a nationwide study of 19, 743 dementia patients in the Swedish Dementia Registry.

Subjective cognitive impairment subjects in our clinical practice.

Heart failure and dementia: survival in relation to types of heart failure and different dementia disorders.

SveDem, the Swedish Dementia Registry - a tool for improving the quality of diagnostics, treatment and care of dementia patients in clinical practice.

mTor mediates tau localization and secretion: Implication for Alzheimer's disease.

Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review.

Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation.

Human brain proteins showing neuron-specific interactions with γ-secretase.

Long-term treatment with active Aβ immunotherapy with CAD106 in mild Alzheimer's disease.

Benchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem.

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.

Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia.

Brain health: a primary health care viewpoint.

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

ADAM10 and BACE1 are localized to synaptic vesicles.

Brain health: the importance of recognizing cognitive impairment: an IAGG consensus conference.

A Practical Guide to Immunoassay Method Validation.

Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease.

Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia Registry.

Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study.

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy.

Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation.

The need for thorough phase II studies in medicines development for Alzheimer's disease.

The Central Biobank and Virtual Biobank of BIOMARKAPD: A Resource for Studies on Neurodegenerative Diseases.

BRICHOS binds to a designed amyloid-forming β-protein and reduces proteasomal inhibition and aggresome formation.

Perforin Promotes Amyloid Beta Internalisation in Neurons.

Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics.

Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Amyloid-Related Imaging Abnormalities (ARIA) in Immunotherapy Trials for Alzheimer's Disease: Need for Prognostic Biomarkers?

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse.

CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia.

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers.

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

Assessment and Reporting of Driving Fitness in Patients with Dementia in Clinical Practice: Data from SveDem, the Swedish Dementia Registry.

Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device.

Evidence-based prevention and treatment of dementia - Authors' reply.

Exploring the prevalence and variance of cognitive impairment, pain, neuropsychiatric symptoms and ADL dependency among persons living in nursing homes; a cross-sectional study.

The worldwide costs of dementia 2015 and comparisons with 2010.

Management of Acute Myocardial Infarction in Patients With Dementia: Data From SveDem, the Swedish Dementia Registry.

BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.

Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2).

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.

Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid.

Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort.

Alzheimer's disease biomarker development: a call to funding bodies.

The biomarker-based diagnosis of Alzheimer's disease. 1-ethical and societal issues.

The biomarker-based diagnosis of Alzheimer's disease. 2-lessons from oncology.

Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia.

Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment.

Living Alone with Alzheimer's Disease: Data from SveDem, the Swedish Dementia Registry.

Consensus guidelines for lumbar puncture in patients with neurological diseases.

Diabetes in a Large Dementia Cohort: Clinical Characteristics and Treatment From the Swedish Dementia Registry.

Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort.

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers.

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.

APP mouse models for Alzheimer's disease preclinical studies.

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.

Thrombolysis in acute ischemic stroke in patients with dementia: A Swedish registry study.

Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons.

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers.

Treatment of Atrial Fibrillation in Patients with Dementia: A Cohort Study from the Swedish Dementia Registry.

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach.

Apolipoprotein E genotypes and longevity across dementia disorders.

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease.

Acute Stroke Care in Dementia: A Cohort Study from the Swedish Dementia and Stroke Registries.

Stroke as a Cause of Death in Death Certificates of Patients with Dementia: A Cohort Study from the Swedish Dementia Registry.

Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.

identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network.

Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses.

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ and Alzheimer Amyloid Plaques.

Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort.

Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen.

Residing in sheltered housing versus ageing in place - Population characteristics, health status and social participation.

Antipsychotic Treatment Associated With Increased Mortality Risk in Patients With Dementia. A Registry-Based Observational Cohort Study.

The MOPEAD project: Advancing patient engagement for the detection of "hidden" undiagnosed cases of Alzheimer's disease in the community.

The thriving of older people assessment scale: Psychometric evaluation and short-form development.

Alzheimer's Disease: Erythrocyte 2,3-diphosphoglycerate Content and Circulating Erythropoietin.

Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.

A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.

Prevention of cognitive decline in old age-varying effects of interventions in different populations.

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products.

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.

Erythrocyte Amyloid Beta Peptide Isoform Distributions in Alzheimer and Mild Cognitive Impairment.

Restoring synaptic function through multimodal therapeutics.

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.

Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity.

Secondary Stroke Prevention After Ischemic Stroke in Patients with Alzheimer's Disease and Other Dementia Disorders.

Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment.

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain.

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

Quantifying and Describing the Natural History and Costs of Alzheimer's Disease and Effects of Hypothetical Interventions.

Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years.

Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.

Regional Disconnection in Alzheimer Dementia and Amyloid-Positive Mild Cognitive Impairment: Association Between EEG Functional Connectivity and Brain Glucose Metabolism.

Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL.

Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance.

Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?

Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain.

Statins, Risk of Death and Ischemic Stroke in Patients with Dementia: A Registry-Based Observational Cohort Study.

General practitioners' attitude toward early and pre-dementia diagnosis of AD in five European countries-A MOPEAD project survey.

The strategic biomarker roadmap for the validation of Alzheimer's diagnostic biomarkers: methodological update.

Biting the Bullet: Firearm Ownership in Persons with Dementia. A Registry-Based Observational Study.

Identification of undiagnosed dementia cases using a web-based pre-screening tool: The MOPEAD project.

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons.

Mortality After Ischemic Stroke in Patients with Alzheimer's Disease Dementia and Other Dementia Disorders.

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe.

Distinctive alteration of presynaptic proteins in the outer molecular layer of the dentate gyrus in Alzheimer's disease.