Kirill Gorshkov

Astrocytes as targets for drug discovery.

A biosensor for MAPK-dependent Lin28 signaling.

Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells.

Advancing precision medicine with personalized drug screening.

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.

Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds.

Induced pluripotent stem cells for neural drug discovery.

Zika Virus: Origins, Pathological Action, and Treatment Strategies.

Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA.

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts.

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.

An OpenData portal to share COVID-19 drug repurposing data in real time.

Cell-Based No-Wash Fluorescence Assays for Compound Screens Using a Fluorescence Cytometry Plate Reader.

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.

Drug Discovery Strategies for SARS-CoV-2.

Development of a high-throughput homogeneous AlphaLISA drug screening assay for the detection of SARS-CoV-2 Nucleocapsid.

Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis.

N-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling.

Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles.

Development of a High-Throughput Homogeneous AlphaLISA Drug Screening Assay for the Detection of SARS-CoV-2 Nucleocapsid.

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.

Zika Virus-Induced Neuronal Apoptosis via Increased Mitochondrial Fragmentation.

Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.

Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1.

Generation of an induced pluripotent stem cell line (TRNDi031-A) from a patient with Alagille syndrome type 1 carrying a heterozygous p. C312X (c. 936 T > A) mutation in JAGGED-1.

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening.

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry.

Fluorescent quantum dots enable SARS-CoV-2 antiviral drug discovery and development.

SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening.

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry.

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease.