Shyue-An Chan
Department of Physiology and Biophysics
Case Western Reserve University
Dr. Shyue-An Chan is a Senior Research Associate in the Department of Physiology and Biophysics in the
Case Western Reserve University School of Medicine in Cleveland, Ohio. He received his Bachelor’s
degree in Biology from National Cheng Kung University in Tainan, Taiwan, and Ph.D. in Anatomical
Sciences and Neurobiology from University of Louisville in Louisville, Kentucky.
Dr. Chan’s Ph.D. training involved in studying the cerebral effect of transient ischemia and demonstrated
the potential neuroprotective effect of fosphenytoin (Cerebyx) for the ischemic neuronal damage of
hippocampus. He join Dr. Corey Smith’s lab in late 1999 as a post-doctoral fellow in Medical College of
Georgia, Augusta, Georgia. The Smith lab moved to Case Western Reserve University at the beginning of
2001, and Dr. Chan started to work as a Research Associate in the CWRU.
The main focus of the Smith lab is in the chromaffin cell physiology, including exocytosis/endocytosis
regulation, control mechanism of catecholamine release, and the stress response of the sympathetic
system. Dr. Chan utilizes patch clamp technique studied chromaffin cells in mouse adrenal slices to
elucidate the molecular steps of catecholamine secretion. Dr. Chan’s studies also demonstrated
different calcium channel’s contribution during different chromaffin cell activity levels. For the stress
response, series of work was conducted involving PACAP was published and support that PACAP elicit
secretion catecholamine preferably under stress condition. Dr. Chan latest works are in detecting
catecholamine and neuropeptide secretion in vivo in collaboration with the UCLA Cardiac Arrhythmia
Center.
Physiological stimuli evoke two forms of endocytosis in bovine chromaffin cells.
The Journal of physiology Dec, 2001 | Pubmed ID: 11744761
Calcium dependence of action potential-induced endocytosis in chromaffin cells.
Pflügers Archiv : European journal of physiology Feb, 2003 | Pubmed ID: 12634923
Low frequency stimulation of mouse adrenal slices reveals a clathrin-independent, protein kinase C-mediated endocytic mechanism.
The Journal of physiology Dec, 2003 | Pubmed ID: 14500763
Action potential stimulation reveals an increased role for P/Q-calcium channel-dependent exocytosis in mouse adrenal tissue slices.
Archives of biochemistry and biophysics Mar, 2005 | Pubmed ID: 15680908
Adrenal chromaffin cells exhibit impaired granule trafficking in NCAM knockout mice.
Journal of neurophysiology Aug, 2005 | Pubmed ID: 15800072
Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2006 | Pubmed ID: 17050729
Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C.
The Journal of physiology Oct, 2007 | Pubmed ID: 17702812
PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway.
Journal of neurochemistry Aug, 2009 | Pubmed ID: 19508428
Enhanced dense core granule function and adrenal hypersecretion in a mouse model of Rett syndrome.
The European journal of neuroscience Aug, 2009 | Pubmed ID: 19674087
Dynamin and myosin regulate differential exocytosis from mouse adrenal chromaffin cells.
Cellular and molecular neurobiology Nov, 2010 | Pubmed ID: 21061163
Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22009744
Reduced calcium current density in female versus male mouse adrenal chromaffin cells in situ.
Cell calcium Sep-Oct, 2012 | Pubmed ID: 22551621
Activity-dependent fusion pore expansion regulated by a calcineurin-dependent dynamin-syndapin pathway in mouse adrenal chromaffin cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2012 | Pubmed ID: 22836276
Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.
American journal of physiology. Cell physiology May, 2014 | Pubmed ID: 24500282
Spatial and activity-dependent catecholamine release in rat adrenal medulla under native neuronal stimulation.
Physiological reports 09, 2016 | Pubmed ID: 27597763
Fast in vivo detection of myocardial norepinephrine levels in the beating porcine heart.
American journal of physiology. Heart and circulatory physiology 05, 2020 | Pubmed ID: 32216617
Rapid measurement of cardiac neuropeptide dynamics by capacitive immunoprobe in the porcine heart.
American journal of physiology. Heart and circulatory physiology 01, 2021 | Pubmed ID: 33095651
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