Changhan Lee

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells.

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris.

Engineering of a human kringle domain into agonistic and antagonistic binding proteins functioning in vitro and in vivo.

Generation of bivalent and bispecific kringle single domains by loop grafting as potent agonists against death receptors 4 and 5.

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

Mitochondria: multifaceted regulators of aging.

Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.

MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Mitonuclear genomics and aging.

Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition.

Mouse Fitness as Determined Through Treadmill Running and Walking.

Remodeling of the H3 nucleosomal landscape during mouse aging.

Mitochondrial-derived peptides in energy metabolism.

Decoding the rosetta stone of mitonuclear communication.

Global spliceosome activity regulates entry into cellular senescence.

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

Aging: All roads lead to mitochondria.

Stress-Responsive Periplasmic Chaperones in Bacteria.

ATP-Independent Chaperones.

Cytoplasmic molecular chaperones in Pseudomonas species.