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Department of Dermatology,
Simmons Comprehensive Cancer Center,
UTSW Comprehensive Neurofibromatosis Clinic,
Hamon Center for Regenerative Science and Medicine
Lu Q. Le has not added Biography.
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Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.
Oncogene Jul, 2007 | Pubmed ID: 17297459
Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development.
Cancer research Jul, 2011 | Pubmed ID: 21551250
Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.
Cancer research Jan, 2014 | Pubmed ID: 24285727
BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction.
Cell reports Jan, 2014 | Pubmed ID: 24373973
Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma.
Cancer cell Nov, 2014 | Pubmed ID: 25446898
Cutaneous neurofibromas in the genomics era: current understanding and open questions.
British journal of cancer Jun, 2018 | Pubmed ID: 29695767
The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities.
Neurology Jul, 2018 | Pubmed ID: 29987131
Spatiotemporal Loss of in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway.
Cancer discovery Jan, 2019 | Pubmed ID: 30348677
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.
Nature communications Nov, 2018 | Pubmed ID: 30479396
Double-Stranded RNA Sensing Determines Epithelial Cell Identity.
The Journal of investigative dermatology Jan, 2019 | Pubmed ID: 30579424
Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research Jun, 2019 | Pubmed ID: 30796033
Heterozygous Tumor Suppressor Microenvironment in Cancer Development.
Trends in cancer Sep, 2019 | Pubmed ID: 31474359
Translating current basic research into future therapies for neurofibromatosis type 1.
British journal of cancer Jul, 2020 | Pubmed ID: 32439933
Human cutaneous neurofibroma matrisome revealed by single-cell RNA sequencing.
Acta neuropathologica communications Jan, 2021 | Pubmed ID: 33413690
Tumorigenesis in neurofibromatosis type 1: role of the microenvironment.
Oncogene Sep, 2021 | Pubmed ID: 34345017
Neurofibromin and suppression of tumorigenesis: beyond the GAP.
Oncogene Feb, 2022 | Pubmed ID: 35066574
Malignant peripheral nerve sheath tumor: models, biology, and translation.
Oncogene Apr, 2022 | Pubmed ID: 35393544
University of Texas Southwestern Medical Center at Dallas
Krystina Rhéaume*,1,
Zhiguo Chen*,2,
Yong Wang*,2,
Camille Plante1,
Dhanushka Hewa Bostanthirige1,
Maude Lévesque1,
Sameh Geha3,4,
Lu Q. Le2,5,6,7,
Jean-Philippe Brosseau1,4
1Department of Biochemistry and Functional Genomics, Université de Sherbrooke,
2Department of Dermatology, University of Texas Southwestern Medical Center at Dallas,
3Department of Pathology, Université de Sherbrooke,
4Centre de Recherche du Centre Hospitalier de Universitaire de Sherbrooke, Université de Sherbrooke,
5Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas,
6UTSW Comprehensive Neurofibromatosis Clinic, University of Texas Southwestern Medical Center at Dallas,
7Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center at Dallas
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