Anmelden

Rui Jorge Nobre

CNC-UC - Center for Neuroscience and Cell Biology,
CIBB - Center for Innovative Biomedicine and Biotechnology,
IIIUC - Institute for Interdisciplinary Research,
ViraVector - Viral Vectors for Gene Transfer Core Facility

University of Coimbra

BIOGRAPHY

Rui Jorge Nobre has not added Biography.

If you are Rui Jorge Nobre and would like to personalize this page please email our Author Liaison for assistance.

PUBLICATIONS

Gene therapy for Parkinson's and Alzheimer's diseases: from the bench to clinical trials.

Current pharmaceutical design , 2011 | Pubmed ID: 21902665

Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.

Human molecular genetics Sep, 2014 | Pubmed ID: 24817574

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9.

Journal of controlled release : official journal of the Controlled Release Society Nov, 2016 | Pubmed ID: 27637390

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line.

Biochimica et biophysica acta. General subjects Mar, 2017 | Pubmed ID: 27939617

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases.

Journal of controlled release : official journal of the Controlled Release Society Sep, 2017 | Pubmed ID: 28687495

Gene Therapies for Polyglutamine Diseases.

Advances in experimental medicine and biology , 2018 | Pubmed ID: 29427115

Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.

Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2018 | Pubmed ID: 30087083

Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders.

Brain : a journal of neurology Feb, 2020 | Pubmed ID: 31738395

Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies.

The Journal of molecular diagnostics : JMD Jun, 2020 | Pubmed ID: 32205289

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.

Journal of translational medicine Apr, 2020 | Pubmed ID: 32272938

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.

Acta neuropathologica communications Aug, 2020 | Pubmed ID: 32867861

Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research.

Molecular therapy. Methods & clinical development Sep, 2020 | Pubmed ID: 32913880

Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening.

Pharmaceutics Oct, 2021 | Pubmed ID: 34683891

miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3.

Nucleic acid therapeutics Jun, 2022 | Pubmed ID: 34878314

Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.

Acta neuropathologica communications Mar, 2022 | Pubmed ID: 35305685

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification.

Gene therapy Dec, 2022 | Pubmed ID: 36316447

Isolation of Extracellular Vesicles from Human Follicular Fluid: Size-Exclusion Chromatography versus Ultracentrifugation.

Biomolecules Feb, 2023 | Pubmed ID: 36830647

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3.

Molecular therapy : the journal of the American Society of Gene Therapy May, 2023 | Pubmed ID: 37025062

RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation.

International journal of biological macromolecules Feb, 2024 | Pubmed ID: 38199539

Viral-based animal models in polyglutamine disorders.

Brain : a journal of neurology Apr, 2024 | Pubmed ID: 38284949

INSTITUTIONS

University of Coimbra

JOVE ARTICLES

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

Miguel M. Lopes^*,1,2,3,

Sara M. Lopes^*,1,2,3,

Rafael Baganha^1,2,4,

Carina Henriques^1,2,5,

Ana C. Silva^1,2,3,

Diana D. Lobo^1,2,3,

Luísa Cortes^1,2,3,6,

Luís Pereira de Almeida^*,1,2,4,5,

Rui Jorge Nobre^*,1,2,3,4

¹CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra,

²CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra,

³IIIUC - Institute for Interdisciplinary Research, University of Coimbra,

⁴ViraVector - Viral Vectors for Gene Transfer Core Facility, University of Coimbra,

⁵FFUC - Faculty of Pharmacy, University of Coimbra,

⁶MICC-CNC - Microscopy Imaging Center of Coimbra - CNC, University of Coimbra

Bioengineering

Datenschutz

Nutzungsbedingungen

Richtlinien

Kontakt

BIBLIOTHEKS-EMPFEHLUNG

JoVE-Newsletter

Forschung

JoVE Journal
Methodensammlungen
JoVE Encyclopedia of Experiments
Archiv

Lehre

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Ressourcen für Lehrende
Faculty Site

Autoren

Übersicht
Veröffentlichungsprozess
Redaktionsausschuss
Umfang und Richtlinien
Peer Review
Häufig gestellte Fragen
Einreichen

Bibliothekare

Übersicht
Erfahrungsberichte
Lizenzen
Zugang
Ressourcen
Bibliotheksbeirat
Häufig gestellte Fragen

ÜBER JoVE

Übersicht
Geschäftsführung
Blog
JoVE Help Center

Rui Jorge Nobre

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}CNC-UC - Center for Neuroscience and Cell Biology,CIBB - Center for Innovative Biomedicine and Biotechnology,IIIUC - Institute for Interdisciplinary Research,ViraVector - Viral Vectors for Gene Transfer Core Facility

University of Coimbra

Isolation of Adeno-Associated Viral Vectors Through a Single-Step and Semi-Automated Heparin Affinity Chromatography Protocol

CNC-UC - Center for Neuroscience and Cell Biology,
CIBB - Center for Innovative Biomedicine and Biotechnology,
IIIUC - Institute for Interdisciplinary Research,
ViraVector - Viral Vectors for Gene Transfer Core Facility