David L. Wiest

Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

Early growth response transcription factors are required for development of CD4(-)CD8(-) thymocytes to the CD4(+)CD8(+) stage.

Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells.

Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection.

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.

Recent insights into the signals that control alphabeta/gammadelta-lineage fate.

T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

High-sensitivity detection and quantitative analysis of native protein-protein interactions and multiprotein complexes by flow cytometry.

Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint.

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.

Early growth response genes regulate B cell development, proliferation, and immune response.

Egr2 is required for Bcl-2 induction during positive selection.

Pre-TCR-induced beta-catenin facilitates traversal through beta-selection.

Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.

Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.

Identification of the last cog in a ligand-independent signaling machine?

Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.

Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.

Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.

Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.

Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization.

Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors.

Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.

CD45-deficient severe combined immunodeficiency caused by uniparental disomy.

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.

Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs.

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification.

Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.

Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength.

Origins of γδ T cell effector subsets: a riddle wrapped in an enigma.

Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Development of γδ T Cells, the Special-Force Soldiers of the Immune System.

Using the Zebrafish Model to Study T Cell Development.

Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.

Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks.

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.

JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia.

Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.

Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.

The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling.

THEMIS-tery is solved.

Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.

Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in .

HEB is required for the specification of fetal IL-17-producing γδ T cells.

Role of a selecting ligand in shaping the murine γδ-TCR repertoire.

Reply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selection.

Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation.

Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.

Functional genomic landscape of acute myeloid leukaemia.

Gadd45 stress sensors in suppression of leukemia.

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.

Recent advances in understanding the development and function of γδ T cells.

NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma.

The E protein-TCF1 axis controls γδ T cell development and effector fate.

Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo.

A Novel Germline Heterozygous Variant Causing Severe Atopic Disease and Immune Dysregulation.

Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.

The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm.

IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma.

Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency.

Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.

Zebrafish: A Tractable Model for Analysis of T Cell Development.

Transcription factor EGR2 controls homing and pathogenicity of T17 cells in the central nervous system.

Doubling down to make killer T cells.

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.

Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death.

E proteins control the development of NKγδT cells through their invariant T cell receptor.