Tom Whitesell

Antisense inhibition of oncogene expression.

Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody.

Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells.

Specific inhibition of oncogene expression in vitro and in vivo by antisense oligonucleotides.

Induction of aP2 gene expression by nonmetabolized long-chain fatty acids.

Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1.

In vivo modulation of N-myc expression by continuous perfusion with an antisense oligonucleotide.

The structure at 198 K of (1R,5R,15R,16R)-5-isopropenyl-2-methyl- 1-[N-(trans-2-phenylcyclohexyloxycarbonyl)amino]-2-cyclohexene.

Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines.

Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100.

Antisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.

Exacerbation of doxorubicin cardiotoxicity by digoxin administration in an experimental rabbit model.

Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.

Evidence that downregulation of hexose transport limits intracellular glucose in 3T3-L1 fibroblasts.

Coronary hyperperfusion and ventricular function in intact and isovolumic pig hearts.

Insulin antagonism of catecholamine stimulation of fatty acid transport in the adipocyte. Studies on its mechanism of action.

Stereocontrolled synthesis of peptide bond isosteres.

Evidence for functionally distinct glucose transporters in basal and insulin-stimulated adipocytes.

Children's reports of conflict between simultaneous opposite-valence emotions.

Activation energy of the slowest step in the glucose carrier cycle: break at 23 degrees C and correlation with membrane lipid fluidity.

Phasic pressures and diameters in small epicardial veins of the unrestrained heart.

Catecholamine activation of the membrane transport of long chain fatty acids in adipocytes is mediated by cyclic AMP and protein kinase.

Stereoselective recognition in phospholipid monolayers.

Maintaining quality in a competitive era.

Temperature dependence of glucose transport in erythrocytes from normal and alloxan-diabetic rats.

Effects of (+)-octanoylcarnitine in intact myocardium.

Meeting the AIDS challenge.

Maintaining our competitive edge.

Adolescent health.

Medical education: the arduous journey leads to more challenges.

Insulin antagonizes epinephrine activation of the membrane transport of fatty acids. Potential site for hormonal suppression of lipid mobilization.

Modulation of basal glucose transporter Km in the adipocyte by insulin and other factors.

Simultaneous transplant nephrectomy and ipsilateral second graft retransplantation.

Treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis with ciprofloxacin or vancomycin alone or in combination with rifampin.

Prepaid health care: a practitioner's perspective.

Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase.

Ascorbic acid recycling enhances the antioxidant reserve of human erythrocytes.

Ascorbate is the major electron donor for a transmembrane oxidoreductase of human erythrocytes.

Regulation of hexokinase II gene transcription and glucose phosphorylation by catecholamines, cyclic AMP, and insulin.

Two regions of GLUT 2 glucose transporter protein are responsible for its distinctive affinity for glucose.

Coupled glucose transport and metabolism in cultured neuronal cells: determination of the rate-limiting step.

Calcium sensitivity of isometric tension is increased in canine experimental heart failure.

Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization.

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP.

Coupling of glucose transport and phosphorylation in Xenopus oocytes and cultured cells: determination of the rate-limiting step.

Relief of spasticity in SCI men and women using rectal probe electrostimulation.

Antisense technology: biological utility and practical considerations.

Occupational lung cancer.

Pulmonary manifestations of extrathoracic malignant lesions.

Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system.

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent.

Functional organization of mammalian hexokinase II. Retention of catalytic and regulatory functions in both the NH2- and COOH-terminal halves.

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

A model of the effects of perceived parent and peer support on adolescent false self behavior.

Altered brain fyn kinase in a murine acquired immunodeficiency syndrome.

Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury.

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

The interpersonal context of emotion: anger with close friends and classmates.

Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate.

Decreased myocardial glucose uptake during ischemia in diabetic swine.

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.

GLUT1 is adequate for glucose uptake in GLUT2-deficient insulin-releasing beta-cells.

The development of multiple role-related selves during adolescence.

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.

Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration.

In situ salt screening--a useful technique for discovery support and preformulation studies.

Relational self-worth: differences in perceived worth as a person across interpersonal contexts among adolescents.

Level of voice among female and male high school students: relational context, support, and gender orientation.

Inhibition of insulin-like growth factor I receptor expression in neuroblastoma cells induces the regression of established tumors in mice.

Molecular chaperones: biology and prospects for pharmacological intervention.

Semiclassical black hole in thermal equilibrium with a nonconformal scalar field.

Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.

Ridicule or recourse: parents falsely accused of past sexual abuse fight back.

Functional interaction between the N- and C-terminal halves of human hexokinase II.

Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.

Inhibition of oncogene expression using vector-generated RNA antisense.

Development and technical basis of simplified guidelines for emergency triage assessment and treatment in developing countries. WHO Integrated Management of Childhood Illness (IMCI) Referral Care Project.

Concurrent centrifugation plasmapheresis and continuous venovenous hemodiafiltration.

Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.

Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.

Tris(3-mercaptopropyl)-N-glycylaminomethane as a new linker to bridge antibody with metal particles for biological cell separations.

Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.

Immunophenotyping using gold or silver nanoparticle-polystyrene bead conjugates with multiple light scatter.

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice.

Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity.

Photochemistry and spectroscopy of "stable organic radicals": steric and electronic effects in intermolecular photoinduced electron transfer.

Glucose uptake and metabolism by cultured human skeletal muscle cells: rate-limiting steps.

Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.

N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution.

Pulse radiolysis studies of dendritic macromolecules with biphenyl peripheral groups and a ruthenium tris-bipyridine core.

Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells.

A dendrimer-based electron antenna: paired electron-transfer reactions in dendrimers with a 4,4'-bipyridine core and naphthalene peripheral groups.

Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava.

Teaching methods.

Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists.

Control of glucose phosphorylation in L6 myotubes by compartmentalization, hexokinase, and glucose transport.

17AAG: low target binding affinity and potent cell activity--finding an explanation.

Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines.

Nanoparticle-cored dendrimers: synthesis and characterization.

Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans.

Novel photoswitchable receptors: synthesis and cation-induced self-assembly into dimeric complexes leading to stereospecific [2+2]-photocycloaddition of styryl dyes containing a 15-crown-5 ether unit.

Design of quinolinedione-based geldanamycin analogues.

Generation of oxidant stress in cultured endothelial cells by methylene blue: protective effects of glucose and ascorbic acid.

The stress response: implications for the clinical development of hsp90 inhibitors.

Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.

Metal-core--organic shell dendrimers as unimolecular micelles.

Beyond the debate: Why some adolescents report stable self-worth over time and situation, whereas others report changes in self-worth.

The influence of core size on electronic coupling in shell-core nanoparticles: gold clusters capped with pyrenoxylalkylthiolate.

Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert.

Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.

Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway.

Electrochemical charging of a fullerene-functionalized self-assembled monolayer on au(111).

Hsp90: an emerging target for breast cancer therapy.

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.

Compartmentalization of transport and phosphorylation of glucose in a hepatoma cell line.

Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata.

Prevalence of DSM-IV disorders and attendant help-seeking in 2 American Indian reservation populations.

Distinct mouse coronary anatomy and myocardial infarction consequent to ligation.

Hsp90 is essential in the filarial nematode Brugia pahangi.

Prevalence of major depressive episode in two American Indian reservation populations: unexpected findings with a structured interview.

Prevalence of mental disorders and utilization of mental health services in two American Indian reservation populations: mental health disparities in a national context.

HSP90 and the chaperoning of cancer.

The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways.

An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.

Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.

Latent class analysis of substance use: comparison of two American Indian reservation populations and a national sample.

HSP90: a rising star on the horizon of anticancer targets.

Help seeking for substance use problems in two American Indian reservation populations.

Synthesis of TiO2 photocatalysts in supercritical CO2 via a non-hydrolytic route.

Heat shock protein 90: a unique chemotherapeutic target.

A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.

Kv2.1 potassium channels are retained within dynamic cell surface microdomains that are defined by a perimeter fence.

Developmental trajectories of personal and collective self-concept among American Indian adolescents.

Intramolecular charge transfer in 1:1 Cu(II)/pyrenylcyclam dendrimer complexes.

Neuroendocrine plasticity in the anterior pituitary: gonadotropin-releasing hormone-mediated movement in vitro and in vivo.

Disparities in drug use and disorder: comparison of two American Indian reservation communities and a national sample.

Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.

A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study.

Marijuana initiation in 2 American Indian reservation communities: comparison with a national sample.

Association between diabetes and mental disorders in two American Indian reservation communities.

A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor.

The relationship of cumulative and proximal adversity to onset of substance dependence symptoms in two American Indian communities.

Directionally aligned helical peptides on surfaces.

Childhood characteristics associated with stage of substance use of American Indians: Family background, traumatic experiences, and childhood behaviors.

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.

Localization and mobility of the delayed-rectifer K+ channel Kv2.1 in adult cardiomyocytes.

The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal.

Stress burden and diabetes in two American Indian reservation communities.

Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.

Alcohol use among American Indian high school youths from adolescence and young adulthood: a latent Markov model.

Effects of an Internet-based intervention for HIV prevention: the Youthnet trials.

2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera.

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.

A longitudinal study of self-esteem, cultural identity, and academic success among American Indian adolescents.

Optical and electrochemical properties of shell-core dendrimers: ruthenium coordination complexes capped with sized phenothiazine-substituted bipyridines.

Reflections on a proposed theory of reservation-dwelling American Indian alcohol use: comment on Spillane and Smith (2007).

Inhibiting the transcription factor HSF1 as an anticancer strategy.

Health-related quality of life and help seeking among American Indians with diabetes and hypertension.

Pilocytic astrocytoma in a child with Noonan syndrome.

Need for related multipronged approaches to understand olfactory bulb signal processing.

pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.

From the top down: flexible reading of a fragmented odor map.

Accuracy of cardiac magnetic resonance of absolute myocardial blood flow with a high-field system: comparison with conventional field strength.

Circle of life: rationale, design, and baseline results of an HIV prevention intervention among young American Indian adolescents of the Northern Plains.

Childhood exposure to adversity and risk of substance-use disorder in two American Indian populations: the meditational role of early substance-use initiation.

The effect of dye density on the efficiency of photosensitization of TiO2 films: light-harvesting by phenothiazine-labelled dendritic ruthenium complexes.

Posttraumatic stress disorder, guilt, depression, and meaning in life among military veterans.

Imaging pattern of intracranial hemorrhage in the setting of posterior reversible encephalopathy syndrome.

Surface effects in water-soluble shell-core hybrid gold nanoparticles in oligonucleotide single strand recognition for sequence-specific bioactivation.

Inflammatory neuropathies.

Selective macrophage ascorbate deficiency suppresses early atherosclerosis.

Factor analyses of condom attitudes, norms, and self-efficacy measures in diverse samples.

Antisense efficacy : site-restricted in vivo and ex vivo models.

Associative cortex features in the first olfactory brain relay station.

Does a nonclassical signaling mechanism underlie an increase of estradiol-mediated gonadotropin-releasing hormone receptor binding in ovine pituitary cells?

Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3.

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

HPV and HPV vaccine education intervention: effects on parents, healthcare staff, and school staff.

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis.

HSP90 as a platform for the assembly of more effective cancer chemotherapy.

Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.

Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.

Inhibiting HSP90 to treat cancer: a strategy in evolution.

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Epidemiology and etiology of substance use among American Indians and Alaska Natives: risk, protection, and implications for prevention.

Patterns of substance use initiation among young adolescents in a Northern Plains American Indian tribe.

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.

Trauma and conditional risk of posttraumatic stress disorder in two American Indian reservation communities.

Differing health care visions.

Interglomerular lateral inhibition targeted on external tufted cells in the olfactory bulb.