Birgit Schilling

Characterization of lipooligosaccharides from Haemophilus ducreyi containing polylactosamine repeats.

Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides.

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.

MS2Assign, automated assignment and nomenclature of tandem mass spectra of chemically crosslinked peptides.

Phosphospecific proteolysis for mapping sites of protein phosphorylation.

Molecular components of a cell death pathway activated by endoplasmic reticulum stress.

Isotopically labeled crosslinking reagents: resolution of mass degeneracy in the identification of crosslinked peptides.

Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis.

A novel lectin, DltA, is required for expression of a full serum resistance phenotype in Haemophilus ducreyi.

Novel modification of lipid A of Francisella tularensis.

Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.

Mass spectrometric identification of a novel phosphorylation site in subunit NDUFA10 of bovine mitochondrial complex I.

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.

Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria.

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.

Novel pathways associated with quinone-induced stress in breast cancer cells.

Characterization of lipid A acylation patterns in Francisella tularensis, Francisella novicida, and Francisella philomiragia using multiple-stage mass spectrometry and matrix-assisted laser desorption/ionization on an intermediate vacuum source linear ion trap.

Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount.

Mitochondrial oxidative stress causes hyperphosphorylation of tau.

Identification of LpxL, a late acyltransferase of Francisella tularensis.

Partial acetylation of lysine residues improves intraprotein cross-linking.

A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells.

Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites.

IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering.

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.

Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.

The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome.

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.

Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach.

A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma.

Identification of new modulators and protein alterations in non-apoptotic programmed cell death.

Confident identification of 3-nitrotyrosine modifications in mass spectral data across multiple mass spectrometry platforms.

ScanRanker: Quality assessment of tandem mass spectra via sequence tagging.

Mass spectrometric identification of novel lysine acetylation sites in huntingtin.

A lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.

Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation.

Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).

Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions.

Site-specific acylation changes in the lipid A of Escherichia coli lpxL mutants grown at high temperatures.

Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma.

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation.

Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.

Panorama: a targeted proteomics knowledge base.

Iron promotes protein insolubility and aging in C. elegans.

Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.

SIRT1 deacetylates RORγt and enhances Th17 cell generation.

Protein acetylation dynamics in response to carbon overflow in Escherichia coli.

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.

Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4.

Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH).

Stable nuclear expression of ATP8 and ATP6 genes rescues a mtDNA Complex V null mutant.

Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers.

Clinical applications of quantitative proteomics using targeted and untargeted data-independent acquisition techniques.

MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments.

Identification and characterization of AckA-dependent protein acetylation in Neisseria gonorrhoeae.

PIQED: automated identification and quantification of protein modifications from DIA-MS data.

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Characterization of Inner and Outer Membrane Proteins fromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates.

An acetylatable lysine controls CRP function in E. coli.

Ancient Regulatory Role of Lysine Acetylation in Central Metabolism.

Protein Turnover in Aging and Longevity.

Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity.

Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Identifying ubiquitinated proteins and aggregates.

Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli.

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose.

Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation.

JNK modifies neuronal metabolism to promote proteostasis and longevity.

Correction for Christensen et al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli".

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.

High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.

Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions.

Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity.

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI.

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species.

A proteomic atlas of senescence-associated secretomes for aging biomarker development.

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ.

Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics.

Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism.

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications.

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.

Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNF-alpha.