Johan Jaenisch

A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Transgenic mice with defined combinations of drug-inducible reprogramming factors.

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals.

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

HIF-1alpha is essential for myeloid cell-mediated inflammation.

Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.

Chromosomal instability and tumors promoted by DNA hypomethylation.

Induction of tumors in mice by genomic hypomethylation.

Stem cells. Setting standards for human embryonic stem cells.

Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics.

Nuclear transplantation, embryonic stem cells, and the potential for cell therapy.

Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2.

Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation.

Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing.

Mice cloned from olfactory sensory neurons.

Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation.

Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis.

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice.

Nuclear transplantation, embryonic stem cells and the potential for cell therapy.

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.

Cre-lox-regulated conditional RNA interference from transgenes.

Reprogramming of a melanoma genome by nuclear transplantation.

Nuclear cloning of embryonal carcinoma cells.

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.

At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation.

Sixteenth Annual Pezcoller Symposium: stem cells and epigenesis in cancer.

Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.

Human cloning - the science and ethics of nuclear transplantation.

X chromosome choice occurs independently of asynchronous replication timing.

Direct in vivo VH to JH rearrangement violating the 12/23 rule.

DNA CpG hypomethylation induces heterochromatin reorganization involving the histone variant macroH2A.

Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor.

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.

Characterization of a highly variable eutherian microRNA gene.

Nuclear cloning, embryonic stem cells, and transplantation therapy.

Nuclear cloning, epigenetic reprogramming and cellular differentiation.

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.

Nuclear cloning, epigenetic reprogramming, and cellular differentiation.

Core transcriptional regulatory circuitry in human embryonic stem cells.

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice.

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis.

Global loss of imprinting leads to widespread tumorigenesis in adult mice.

Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts.

Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable.

The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression.

A simple system of checks and balances to cut fraud.

Politically correct human embryonic stem cells?

Suppression of intestinal neoplasia by deletion of Dnmt3b.

DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.

Polycomb complexes repress developmental regulators in murine embryonic stem cells.

Control of developmental regulators by Polycomb in human embryonic stem cells.

NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.

Nuclear reprogramming and pluripotency.

Mammalian nuclear transfer.

Molecular control of pluripotency.

Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.

On the cloning of animals from terminally differentiated cells.

Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.

Commentary: isolated stem cells--patentable as cultural artifacts?

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Analysis of genetic polymorphism in select vaccine candidate antigens and microsatellite loci in Plasmodium falciparum from endemic areas at varying altitudes.

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.

Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.

A chromatin landmark and transcription initiation at most promoters in human cells.

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.

Strategies to induce nuclear reprogramming.

YAP1 increases organ size and expands undifferentiated progenitor cells.

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin.

Oct4 expression is not required for mouse somatic stem cell self-renewal.

The pluripotency regulator Oct4: a role in somatic stem cells?

Assessment and minimization of contralateral breast dose for conventional and intensity modulated breast radiotherapy.

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming.

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer.

New advances in iPS cell research do not obviate the need for human embryonic stem cells.

c-Myc is dispensable for direct reprogramming of mouse fibroblasts.

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.

Dissecting direct reprogramming through integrative genomic analysis.

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development.

Somatic cell nuclear transfer and derivation of embryonic stem cells in the mouse.

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.

Genome-scale DNA methylation maps of pluripotent and differentiated cells.

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression.

Wnt signaling promotes reprogramming of somatic cells to pluripotency.

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.

Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET.

Interview with Rudolf Jaenisch, M.D.

Nanoparticles for gene transfer to human embryonic stem cell colonies.

A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.

Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.

H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.

Reprogramming of somatic cell identity.

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.

Derivation and manipulation of murine embryonic stem cells.

Reprogramming of murine and human somatic cells using a single polycistronic vector.

Celebrating 10 years of hESC lines: an interview with Rudolf Jaenisch.

Microfluidic control of cell pairing and fusion.

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Broader implications of defining standards for the pluripotency of iPSCs.

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Identification of ischemic regions in a rat model of stroke.

Epigenetic hierarchy governing Nestin expression.

HDAC2 negatively regulates memory formation and synaptic plasticity.

Metastable pluripotent states in NOD-mouse-derived ESCs.

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.

Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility.

Stem cells, pluripotency and nuclear reprogramming.

Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases.

Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro.

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Direct cell reprogramming is a stochastic process amenable to acceleration.

Technical challenges in using human induced pluripotent stem cells to model disease.

Single-gene transgenic mouse strains for reprogramming adult somatic cells.

TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.

Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia.

Malaria incidence and prevalence on Pemba island before the onset of the successful control intervention on the Zanzibar archipelago.

Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells.

Generation of iPSCs from cultured human malignant cells.

Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.

Two-step imprinted X inactivation: repeat versus genic silencing in the mouse.

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. 1990.

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

Planned complex suicide: Self-strangulation and plaster ingestion.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Reprogramming of human peripheral blood cells to induced pluripotent stem cells.

Epigenetic memory in induced pluripotent stem cells.

Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells.

Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.

Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis.

T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.

Histone H3K27ac separates active from poised enhancers and predicts developmental state.

Gene targeting in human pluripotent cells.

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.

Usefulness and applicability of the revised dengue case classification by disease: multi-centre study in 18 countries.

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors.

A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.

Genetic engineering of human pluripotent cells using TALE nucleases.

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects.

Respiratory muscle training improves hemodynamics, autonomic function, baroreceptor sensitivity, and respiratory mechanics in rats with heart failure.

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.

Blimp1 expression predicts embryonic stem cell development in vitro.

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.

Comparison of the effect of different methods of molt: production and welfare evaluation.

Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells.

Contributions of polyclonal malaria, gametocytemia, and pneumonia to infant severe anemia incidence in malaria hyperendemic Pemba, Tanzania.

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.

CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection.

IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.

Low-level laser therapy improves the inflammatory profile of rats with heart failure.

Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors.

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase.

Transdifferentiation by defined factors as a powerful research tool to address basic biological questions.

Medicine. iPSC disease modeling.

Nuclear cloning and direct reprogramming: the long and the short path to Stockholm.

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium.

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.

Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.

Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.

Matrix remodeling maintains embryonic stem cell self-renewal by activating stat3.

SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.

The global distribution and burden of dengue.

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering.

TALEN-mediated editing of the mouse Y chromosome.

Mechanisms and models of somatic cell reprogramming.

Towards eliminating HLA class I expression to generate universal cells from allogeneic donors.