Gerhard J. Schutz

Ultrasensitive pharmacological characterisation of the voltage-gated potassium channel K(V)1.3 studied by single-molecule fluorescence microscopy.

Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains.

Cadherin function probed by laser tweezer and single molecule fluorescence in vascular endothelial cells.

Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts.

Visualization of vesicle transport along and between distinct pathways in neurites of living cells.

Ultra-sensitive fluorescence reader for bioanalysis.

Single-molecule reader for high-throughput bioanalysis.

Visualization of the uptake of individual HDL particles in living cells via the scavenger receptor class B type I.

SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux.

A combined optical and atomic force microscope for live cell investigations.

RNA expression profiling at the single molecule level.

A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation.

(Un)confined diffusion of CD59 in the plasma membrane determined by high-resolution single molecule microscopy.

Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement.

How the sum of its parts gets greater than the whole.

High throughput FRET screening of the plasma membrane based on TIRFM.

Implementation of alternating excitation schemes in a biochip-reader for quasi-simultaneous multi-color single-molecule detection.

Tracking single molecules in the live cell plasma membrane-Do's and Don't's.

Different types of cell-to-cell connections mediated by nanotubular structures.

Versatile analysis of single-molecule tracking data by comprehensive testing against Monte Carlo simulations.

Micropatterning for quantitative analysis of protein-protein interactions in living cells.

Plasma membrane fluidity affects transient immobilization of oxidized phospholipids in endocytotic sites for subsequent uptake.

Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck.

Direct observation and quantitative analysis of Lck exchange between plasma membrane and cytosol in living T cells.

Microarray analysis at single-molecule resolution.

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

Identification of immobile single molecules using polarization-modulated asynchronous time delay and integration-mode scanning.

Temporal resolution of protein-protein interactions in the live-cell plasma membrane.

Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning.

Antimicrobial and immunostimulatory peptide, KLK, induces an increase in cytosolic Ca²(+) concentration by mobilizing Ca²(+) from intracellular stores.

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.

Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane.

Single-molecule detection on a protein-array assay platform for the exposure of a tuberculosis antigen.

Spot variation fluorescence correlation spectroscopy allows for superresolution chronoscopy of confinement times in membranes.

Cationic amphipathic peptides accumulate sialylated proteins and lipids in the plasma membrane of eukaryotic host cells.

What can we learn from single molecule trajectories?

Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts.

VEGF-INDUCED ENDOTHELIAL CELL MIGRATION REQUIRES UROKINASE RECEPTOR (uPAR)-DEPENDENT INTEGRIN REDISTRIBUTION.

Detection and Quantification of Biomolecular Association in Living Cells using Single-Molecule Microscopy.