Department of Oncology
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¹⁸F-labeled silicon-based fluoride acceptors: potential opportunities for novel positron emitting radiopharmaceuticals.
BioMed research international , 2014 | Pubmed ID: 25157357
5-(4-((4-[(18)F]Fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: a selective dual inhibitor for potential PET imaging of Trk/CSF-1R.
Bioorganic & medicinal chemistry letters Oct, 2014 | Pubmed ID: 25257201
In Vivo Evaluation of ¹⁸F-SiFAlin-Modified TATE: A Potential Challenge for ⁶⁸Ga-DOTATATE, the Clinical Gold Standard for Somatostatin Receptor Imaging with PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Jul, 2015 | Pubmed ID: 25977461
Improving the stability of peptidic radiotracers by the introduction of artificial scaffolds: which structure element is most useful?
Journal of labelled compounds & radiopharmaceuticals Aug, 2015 | Pubmed ID: 26219022
Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.
Expert opinion on therapeutic patents , 2016 | Pubmed ID: 26561352
From Unorthodox to Established: The Current Status of (18)F-Trifluoroborate- and (18)F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging.
Bioconjugate chemistry Feb, 2016 | Pubmed ID: 26566577
Recent Advances in the Development and Application of Radiolabeled Kinase Inhibitors for PET Imaging.
Molecules (Basel, Switzerland) Dec, 2015 | Pubmed ID: 26690113
Radiosynthesis and Preclinical Evaluation of F-Fluoroglycosylated Octreotate for Somatostatin Receptor Imaging.
Bioconjugate chemistry Nov, 2016 | Pubmed ID: 27715017
Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.
Expert opinion on therapeutic patents Jun, 2017 | Pubmed ID: 28270010
Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.
Expert opinion on therapeutic patents Jul, 2017 | Pubmed ID: 28270021
Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development.
Bioorganic & medicinal chemistry letters 06, 2017 | Pubmed ID: 28476569
A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human.
Journal of medicinal chemistry 08, 2017 | Pubmed ID: 28696690
Small Prosthetic Groups in F-Radiochemistry: Useful Auxiliaries for the Design of F-PET Tracers.
Seminars in nuclear medicine 09, 2017 | Pubmed ID: 28826522
Automated synthesis of PET radiotracers by copper-mediated F-fluorination of organoborons: Importance of the order of addition and competing protodeborylation.
Journal of labelled compounds & radiopharmaceuticals 03, 2018 | Pubmed ID: 29143408
Synthesis, in vitro and in vivo evaluation of F-fluoronorimatinib as radiotracer for Imatinib-sensitive gastrointestinal stromal tumors.
Nuclear medicine and biology 02, 2018 | Pubmed ID: 29175467
F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles.
Bioconjugate chemistry 01, 2018 | Pubmed ID: 29202229
Identification of [F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging.
Journal of medicinal chemistry 02, 2018 | Pubmed ID: 29257860
Recent Advances in F Radiochemistry: A Focus on B-F, Si-F, Al-F, and C-F Radiofluorination via Spirocyclic Iodonium Ylides.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 04, 2018 | Pubmed ID: 29284673
Gastrin-Releasing Peptide Receptor- and Prostate-Specific Membrane Antigen-Specific Ultrasmall Gold Nanoparticles for Characterization and Diagnosis of Prostate Carcinoma via Fluorescence Imaging.
Bioconjugate chemistry 05, 2018 | Pubmed ID: 29542916
Design, synthesis and in vitro evaluation of heterobivalent peptidic radioligands targeting both GRP- and VPAC-Receptors concomitantly overexpressed on various malignancies - Is the concept feasible?
European journal of medicinal chemistry Jul, 2018 | Pubmed ID: 29864700
Design, Synthesis, In Vitro, and Initial In Vivo Evaluation of Heterobivalent Peptidic Ligands Targeting Both NPY(Y₁)- and GRP-Receptors-An Improvement for Breast Cancer Imaging?
Pharmaceuticals (Basel, Switzerland) Jul, 2018 | Pubmed ID: 29973529
iEDDA Conjugation Reaction in Radiometal Labeling of Peptides with Ga and Cu: Unexpected Findings.
ACS omega Oct, 2018 | Pubmed ID: 30411057
Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.
Pharmaceuticals (Basel, Switzerland) Jan, 2019 | Pubmed ID: 30609832
First-in-Human Brain Imaging of [F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.
ACS chemical neuroscience Jun, 2019 | Pubmed ID: 31017386
David Connolly*,1,
Justin J. Bailey*,1,
Harun Ilhan2,3,
Peter Bartenstein2,3,
Carmen Wängler4,
Björn Wängler5,
Melinda Wuest1,
Frank Wuest1,
Ralf Schirrmacher1
1Department of Oncology, University of Alberta,
2Department of Nuclear Medicine, University Hospital of Munich,
3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich,
4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University,
5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University
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