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University Medicine Göttingen

2 ARTICLES PUBLISHED IN JoVE

Medicine

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

René Günther¹, Martin Suhr¹, Jan C. Koch¹, Mathias Bähr^1,2, Paul Lingor^1,2, Lars Tönges¹

¹Dept. of Neurology, University Medicine Göttingen, ²DFG Research Center for the Molecular Physiology of the Brain (CMPB), Göttingen, Germany

A mouse model for amyotrophic lateral sclerosis (ALS) is examined clinically and behaviorally. As a prerequisite for an accompanying immunohistological analysis the preparation of the spinal cord is depicted in detail.

Neuroscience

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Katharina Schregel^1,2, Daniel Behme¹, Ioannis Tsogkas¹, Michael Knauth¹, Ilko Maier³, André Karch⁴, Rafael Mikolajczyk^4,5, Mathias Bähr³, Jörn Schäper⁶, José Hinz⁶, Jan Liman³, Marios-Nikos Psychogios¹

¹Institute of Neuroradiology, University Medical Center Goettingen, ²Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, ³Department of Neurology, University Medical Center Goettingen, ⁴Department of Epidemiology, Helmholtz Center for Infection Research, ⁵Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, ⁶Department of Anesthesiology, University Medical Center Goettingen

The outcome of patients with acute ischemic stroke depends on swift restoration of cerebral blood flow. This protocol aims at optimizing the management of such patients by minimizing peri-procedural timings and rendering the time from hospital admission to reperfusion as short as possible.