Engineered 3D Silk-collagen-based Model of Polarized Neural TissueKarolina Chwalek 1, Disha Sood 1, William L. Cantley 1, James D. White 1, Min Tang-Schomer 2, David L. Kaplan 1
1Department of Biomedical Engineering, Tufts University, 2Department of Pediatrics, University of Connecticut Health Center & Connecticut Children's Medical Center
Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.
