Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula EndotheliumTakuya Hashimoto 1,2,3, Kota Yamamoto 1,2,3, Trenton Foster 1, Hualong Bai 1, Kunihiro Shigematsu 4, Alan Dardik 1,3
1Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University, 2Department of Vascular Surgery, University of Tokyo, 3Department of Vascular Surgery, VA Connecticut Healthcare Systems, 4Department of Vascular Surgery, International University of Health and Welfare Mita Hospital
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
