Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small AnimalsPhillip G. Durham 1, Shumaila N. Hanif 2, Lucia Garcia Contreras 2, Ellen F. Young 3, Miriam S. Braunstein 3, Anthony J. Hickey 1
1RTI International, 2Oklahoma University Health Science Center, 3University of North Carolina at Chapel Hill
During development of drugs for pulmonary delivery, it is necessary to evaluate pharmacokinetics and efficacy in an animal model. We present a method to build a disposable aerosol dispersion system from of-the-shelf components that can be used to administer intrapulmonary dry powder aerosol to rodents.
