Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain CircuitryWilson Wang *1, Yanrong Zhang *2, Matthew J. Anzivino 1, Edward H. Bertram 3, James Woznak 1,4, Alexander Klibanov 5, Erik Dumont 6, Max Wintermark *2, Kevin S. Lee *1,7,8
1Department of Neuroscience, University of Virginia, 2Department of Radiology, Stanford University, 3Department of Neurology, University of Virginia, 4Global Internship Program, Focused Ultrasound Foundation, 5Department of Medicine, University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery, University of Virginia, 8Center for Brain, Immunology, and Glia, University of Virginia
The goal of the protocol is to provide a method for producing non-invasive neuronal lesions in the brain. The method utilizes Magnetic Resonance-guided Focused Ultrasound (MRgFUS) to open the Blood Brain Barrier in a transient and focal manner, in order to deliver a circulating neurotoxin to the brain parenchyma.
