Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug CombinationsChristina Isber 1, David L. Stockman 2, Ziad Daoud 2,3
1Faculty of Medicine and Medical Sciences, University of Balamand, 2Department of Clinical Microbiology, Michigan Health Clinics, 3College of Medicine, Central Michigan University
This protocol describes how to study all possible combinations that can be obtained between four drugs in one single experiment. This method is based on the standard 96-well plate micro dilution assay and the calculation of fractional inhibitory concentrations (FICs) to evaluate the results.
