Anmelden

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that form cross-bridges between the components. For example, the linker protein spectraplakin bridges microtubules with actin filaments, and KASH proteins link the nucleus to the cytoskeleton. Indirect communication is mediated via signaling cascades, such as those involving the Rho proteins.

Rho, the Master Regulators

The small GTPases of the Rho family proteins, such as RhoA, Cdc42, and Rac1, are the master regulators in establishing cell polarity by acting on all three cytoskeletal components. For example, Cdc42 not only directs actin reorganization at the leading edge but also reorganizes intermediate filaments by regulating their transport on the microtubules. The microtubules also direct the transport of various proteins and vesicles, which, in turn, regulate actin dynamics at the leading edge. Such positive feedback helps maintain the synchronized polarity of the different cytoskeletal components.

Tags

Cell MigrationCytoskeletonActin FilamentsIntermediate FilamentsMicrotubulesCytoskeletal CrosstalkLinker ProteinsSpectraplakinKASH ProteinsRho ProteinsRho GTPasesRhoACdc42Rac1Cell PolarityActin ReorganizationIntermediate Filament TransportMicrotubule based TransportPositive Feedback

Aus Kapitel 30:

article

Now Playing

30.11 : Koordinierung des Zytoskeletts bei der Zellmigration

Zellpolarisierung und Migration

4.7K Ansichten

article

30.1 : Zellmigration

Zellpolarisierung und Migration

4.6K Ansichten

article

30.2 : Aktinpolymerisation und Zellmotilität

Zellpolarisierung und Migration

4.8K Ansichten

article

30.3 : Arten von Membranauswüchsen

Zellpolarisierung und Migration

2.7K Ansichten

article

30.4 : Mechanismus der Bildung von Lamellipodien

Zellpolarisierung und Migration

2.4K Ansichten

article

30.5 : Mechanismus der Filopodien-Bildung

Zellpolarisierung und Migration

2.2K Ansichten

article

30.6 : Migration von Krebszellen durch Invadopodien

Zellpolarisierung und Migration

2.2K Ansichten

article

30.7 : Zellmotilität durch Blebbing

Zellpolarisierung und Migration

1.8K Ansichten

article

30.8 : Die Rolle von Myosin bei der Zellmigration

Zellpolarisierung und Migration

2.2K Ansichten

article

30.9 : Zellpolarisierung durch Rho-Proteine

Zellpolarisierung und Migration

2.6K Ansichten

article

30.10 : Chemotaxis und Richtung der Zellmigration

Zellpolarisierung und Migration

3.3K Ansichten

JoVE Logo

Datenschutz

Nutzungsbedingungen

Richtlinien

Forschung

Lehre

ÜBER JoVE

Copyright © 2025 MyJoVE Corporation. Alle Rechte vorbehalten