JoVE Logo

Anmelden

6.3 : Adrenergic Receptors: ɑ Subtype

Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:

Adrenaline ≥ Noradrenaline >> Isoprenaline

α-adrenoceptors are further divided into α1 and α2-adrenoceptors.

α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase C—inositol-1,4,5-trisphosphate (IP3)—diacylglycerol (DAG) pathway.

α2-Adrenoceptors: α2-adrenoceptors are predominantly located on the presynaptic nerve endings, which control noradrenaline release. They are also found on presynaptic parasympathetic neurons. Noradrenaline released from a presynaptic sympathetic interacting with these receptors causes inhibition of ACh release. In contrast to α1 receptors, activation of α2 receptors causes inhibition of adenylyl cyclase, decreased intracellular cAMP levels, and closure of ion channels.

Further subdivisions: The α1 and α2 receptors are further classified into α1A, α1B, α1D and α2A, α2B, α2C subtypes, respectively, for a better understanding of drug-receptor selectivity.

Tags

Adrenergic ReceptorsAdrenoceptorsCatecholamine AgonistsadrenoceptorsadrenoceptorsPhospholipase CInositol 145 trisphosphateDiacylglycerolPresynaptic Nerve EndingsNoradrenaline ReleaseAdenylyl CyclaseCAMP LevelsDrug receptor Selectivity

Aus Kapitel 6:

article

Now Playing

6.3 : Adrenergic Receptors: ɑ Subtype

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

1.4K Ansichten

article

6.1 : Adrenerge Neuronen: Neurotransmission

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

3.4K Ansichten

article

6.2 : Adrenerge Rezeptoren (Adrenozeptoren): Klassifikation

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

2.2K Ansichten

article

6.4 : Adrenerge Rezeptoren: β Subtyp

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

1.5K Ansichten

article

6.5 : Adrenerge Agonisten: Direkt wirkende Wirkstoffe

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

1.4K Ansichten

article

6.6 : Adrenerge Agonisten: indirekt wirkende Agenzien

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

1.5K Ansichten

article

6.7 : Adrenerge Agonisten: Mixed-Action-Wirkstoffe

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

660 Ansichten

article

6.8 : Adrenerge Agonisten: Chemie und Struktur-Wirkungs-Beziehung

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

2.5K Ansichten

article

6.9 : Adrenerge Agonisten: Therapeutische Klassifikation

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

705 Ansichten

article

6.10 : Adrenerge Agonisten: Therapeutische Anwendungen

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

724 Ansichten

article

6.11 : Adrenerge Antagonisten: Chemie und Klassifikation von ɑ-Rezeptorblockern

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

803 Ansichten

article

6.12 : Adrenerge Antagonisten: Pharmakologische Wirkungen von ɑ-Rezeptor-Blockern

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

533 Ansichten

article

6.13 : Adrenerge Antagonisten: Chemie und Klassifikation von β-Rezeptor-Blockern

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

517 Ansichten

article

6.14 : Adrenerge Antagonisten: Pharmakologische Wirkungen von β-Rezeptor-Blockern

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

528 Ansichten

article

6.15 : Adrenerge Antagonisten: ɑ und β-Rezeptor-Blocker

Drugs Acting on Autonomic Nervous System: Adrenergic Agonists and Antagonists Agents

405 Ansichten

See More

JoVE Logo

Datenschutz

Nutzungsbedingungen

Richtlinien

Forschung

Lehre

ÜBER JoVE

Copyright © 2025 MyJoVE Corporation. Alle Rechte vorbehalten