Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.

These agents can be classified based on their selectivity to specific adrenoceptor types. Non-selective agents, like oxymetazoline, have diverse effects. Selective direct-acting agonists target specific adrenoceptors, avoiding unwanted side effects. Examples include α1-selective agents (e.g., phenylephrine) that enhance cardiovascular function, α2-selective agents that inhibit it, ꞵ1-selective agents (e.g., dobutamine) that increase heart rate and cardiac output, and ꞵ2-selective agents (e.g., salbutamol, terbutaline) that act as bronchodilators and uterine relaxants. Additionally, ꞵ3-selective agents like mirabegron are used to treat urinary incontinence by acting on the detrusor muscle of the bladder.

Tags
Adrenergic AgonistsSympathomimeticsDirect acting AgentsAdrenoceptorsNon selective AgentsSelective AgonistsCardiovascular FunctionBronchodilatorsUrinary IncontinenceCatecholamines

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6.5 : Adrenergic Agonists: Direct-Acting Agents

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6.1 : Adrenerge Neuronen: Neurotransmission

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6.2 : Adrenerge Rezeptoren (Adrenozeptoren): Klassifikation

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6.3 : Adrenerge Rezeptoren: ɑ Subtyp

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6.4 : Adrenerge Rezeptoren: β Subtyp

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6.6 : Adrenerge Agonisten: indirekt wirkende Agenzien

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6.7 : Adrenerge Agonisten: Mixed-Action-Wirkstoffe

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6.8 : Adrenerge Agonisten: Chemie und Struktur-Wirkungs-Beziehung

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6.9 : Adrenerge Agonisten: Therapeutische Klassifikation

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6.10 : Adrenerge Agonisten: Therapeutische Anwendungen

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6.11 : Adrenerge Antagonisten: Chemie und Klassifikation von ɑ-Rezeptorblockern

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6.12 : Adrenerge Antagonisten: Pharmakologische Wirkungen von ɑ-Rezeptor-Blockern

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6.13 : Adrenerge Antagonisten: Chemie und Klassifikation von β-Rezeptor-Blockern

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6.14 : Adrenerge Antagonisten: Pharmakologische Wirkungen von β-Rezeptor-Blockern

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6.15 : Adrenerge Antagonisten: ɑ und β-Rezeptor-Blocker

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