Name: Training Prior to Executing Tuina on Knee Osteoarthritis Rabbit Model
Uploaded: 2023-08-25T14:15:00
Description: Watch this Scientific Journal Video about Training Prior to Executing Tuina on Knee Osteoarthritis Rabbit Model at JoVE.com

training prior to executing tuina on knee osteoarthritis rabbit model

Treating Knee Osteoarthritis with Tuina in a Rabbit Model

Knee osteoarthritis (KOA) is a degenerative disease of the knee joint, mainly manifested by knee pain, swelling, deformation, and restricted movement, with a high disability rate and a higher prevalence in women, with 527.81 million patients with osteoarthritis worldwide in 2019 and its global prevalence accounting for 60.6% of the total global prevalence of OA1. Clinically, the treatment of KOA is usually divided into non-surgical and surgical therapies. Non-surgical therapies include physiotherapy, pharmacotherapy, and platelet-rich plasma injection therapy2,3. Tuina is a common, safe, reliable, and effective treatment method in Chinese medicine. This study uses Tuina combined with the knee joint rotary correction method to treat KOA. Tuina techniques such as the rotatory kneading and pressing method can balance muscle tissue, reduce pain, adjust inflammatory factor levels, improve tissue metabolism, and inhibit articular cartilage degeneration4,5. The knee joint rotary correction method can adjust the alignment of lower limb bones and joints, improve the knee joint gap, restore the normal force line, and balance the lower limb biomechanics6,7,8,9. Resistance exercises can enhance muscle mass and strength and promote cartilage tissue renewal10,11. A preliminary study found that this Tuina protocol is significantly more effective than oral glucosamine sulfate capsules in treating KOA, with a faster onset of action and significant inhibition of chondrocyte degeneration and repair of damaged cartilage tissue12. In the treatment of KOA, compared to Tuina therapy, non-steroidal anti-inflammatory drugs have adverse effects and unsatisfactory long-term efficacy, relatively high surgical risks and costs, and require certain indications for surgical treatment, with postoperative problems and periprosthetic complications13,14,15. When compared to drug therapy and surgery, Tuina treatment for KOA offers several advantages, including reduced side effects, lower risk, enhanced safety, cost-effectiveness, and longer-lasting efficacy. Additionally, it can effectively alleviate knee joint pain, swelling, popping, and restricted movement6,13,16,17.
However, the mechanism of Tuina for the treatment of KOA needs to be clarified, which limits the improvement and perfection of the treatment protocol for KOA. Therefore, studying the mechanism of Tuina intervention in KOA through animal experiments is an effective method. Rabbits, compared to rats, have a docile temperament and larger knee joints. The anatomical structure and cartilage biochemical indexes are similar to those of humans, so it is a suitable subject for studying the mechanism of knee joint disease by Tuina18. The KOA model established by injecting papain into the knee joint cavity of rabbits has the advantages of short modeling time, reduced trauma, high success rate, high survival rate, and similar pathological mechanism to KOA19. This study aims to establish a scientifically feasible animal experimental protocol for Tuina intervention in KOA and investigate the mechanism of Tuina.

Author Spotlight: Using a Rabbit Model to Explore the Efficacy of Tuina in Treating Knee Osteoarthritis 

Tuina Intervention in Rabbit Model of Knee Osteoarthritis

When comparing the two types of therapy and the surgery, tuina treatment of full knee osteoarthritis offered several advantages, including reduced side effects, lower risk, enhanced safety, cost effectiveness, and longer-lasting efficacy. Additionally, it can effectively eliminate knee joint pain, swelling, popping, and restricted movement. This study offers scientifically sound, an affordable research particular, that will aid in exploring the mechanism underlying the effectiveness of tuina in the treatment of knee joint diseases.This study demonstrates the scientific feasibility of tuina treatment for knee osteoarthritis model rabit, highlighting its potential application in the study of knee osteoarthritis, and a similar knee joint-related conditions.

Watch this Scientific Journal Video about Training Prior to Executing Tuina on Knee Osteoarthritis Rabbit Model at JoVE.com

Training Prior to Executing Tuina on Knee Osteoarthritis Rabbit Model

Initiate training using the Tuina Technique Parameter Determination Tool prior to executing the Tuina manipulation. To do so, on the Tuina Manipulation Simulation Platform, perform the rotary kneading and pressing method using the thumb. At the same time, in the Tuina Manipulation Parameter Processing Software observe the magnitude, frequency, and duration of action of the applied force across the x, y, and z-axes.Standardize the training in an applied force of five newtons and a frequency of 60 times per minute. Maintain the standardized rotary kneading and pressing continuously for an operation time of 10 minutes.

Research

JoVE Journal

Medicine

Knee osteoarthritis (KOA) is mainly characterized by degenerative changes in the knee joint's cartilage and surrounding soft tissues. The efficacy of ...