Results: Scope of Umpolung Functionalization of Ketones
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Conclusion
Transkript
Umpolung of ketone enolates by virtue of reversing natural activity, enables the development of unprecedented reactions to functionalized carbon neo-compounds. The key is the formation of electrophilic enolonium species as a discreet species. A ma
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A two step one-pot protocol for the umpolung of ketone enolates to enolonium species and addition of a nucleophile to the α-position is described. Nucleophiles include chloride, azide, azoles, allyl-silanes, and aromatic compounds.