Carbodiimide Coupling Reaction for Primary Alcohols and Extraction Workup
2:17
Washing Procedure
3:28
Carbodiimide Coupling Reaction for Secondary and Electron-deficient Alcohols
4:12
Carbodiimide Coupling Reaction for Long-Chain or Hydrophobic Carboxylic Acids
4:54
Results: Characterization of Esters Formed from the Greener Steglich Esterification
6:32
Conclusion
Transkript
The overall goal of this experiment is to provide a greener methodology for a common esterification reaction, which could serve useful for estro-synthesis in academic and industrial applications. Our method can be used for efficient and mild synth
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A modified Steglich esterification reaction was used to synthesize a small library of ester derivatives with primary and secondary alcohols. The methodology uses a non-halogenated and greener solvent, acetonitrile, and enables product isolation in high yields without the need for chromatographic purification.