Dalibor Sames

Total synthesis of (-)-rhazinilam: asymmetric C[bond]H bond activation via the use of a chiral auxiliary.

Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains.

C-C bond formation via C-H bond activation: synthesis of the core of teleocidin B4.

C-C bond formation via C-H bond activation: catalytic arylation and alkenylation of alkane segments.

Pt(IV)-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation.

Selective C-arylation of free (NH)-heteroarenes via catalytic C-H bond functionalization.

Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling.

Diversity synthesis via C-H bond functionalization: concept-guided development of new C-arylation methods for imidazoles.

Cobalt-catalyzed arylation of azole heteroarenes via direct C-H bond functionalization.

Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation.

Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine.

Ru(III)-catalyzed cyclization of arene-alkene substrates via intramolecular electrophilic hydroarylation.

New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases.

Cross-coupling of sp(3) C-H bonds and alkenes: catalytic cyclization of alkene-amide substrates.

Direct C-H bond arylation: selective palladium-catalyzed C2-arylation of N-substituted indoles.

Oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization.

Two-photon induced uncaging of a reactive intermediate. Multiphoton in situ detection of a potentially valuable label for biological applications.

Site-specific phenylation of pyridine catalyzed by phosphido-bridged ruthenium dimer complexes: a prototype for C-H arylation of electron-deficient heteroarenes.

Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B).

Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ.

Selective and catalytic arylation of N-phenylpyrrolidine: sp3 C-H bond functionalization in the absence of a directing group.

Direct palladium-catalyzed C-2 and C-3 arylation of indoles: a mechanistic rationale for regioselectivity.

A new fluorogenic transformation: development of an optical probe for coenzyme Q.

Room temperature hydroalkylation of electron-deficient olefins: sp3 C-H functionalization via a lewis acid-catalyzed intramolecular redox event.

Room temperature intramolecular hydro-O-alkylation of aldehydes: sp3 C-H functionalization via a Lewis acid catalyzed tandem 1,5-hydride transfer/cyclization.

Fluoromorphic substrates for fatty acid metabolism: highly sensitive probes for mammalian medium-chain acyl-CoA dehydrogenase.

Selective and catalytic arylation of N-phenylpyrrolidine: (sp3) C-H bond functionalization in the absence of a directing group [J. Am. Chem. Soc. 2005, 127, 5284-5285].

Oxidative C-arylation of free (NH)-heterocycles via direct sp3 C-H bond functionalization [J. Am. Chem. Soc. 2004, 126, 13244-13246].

C-H bond functionalization in complex organic synthesis.

Catalytic C-H arylation of SEM-protected azoles with palladium complexes of NHCs and phosphines.

Phosphorylation state-responsive lanthanide peptide conjugates: a luminescence switch based on reversible complex reorganization.

Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells.

Synthesis of luminescent heterometallic bis-lanthanide complexes via selective, sequential metallation.

sp3 C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines.

Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles.

Cocktails of Tb(3+) and Eu(3+) complexes: a general platform for the design of ratiometric optical probes.

Transposing molecular fluorescent switches into the near-IR: development of luminogenic reporter substrates for redox metabolism.

Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.

Harnessing functional plasticity of enzymes: a fluorogenic probe for imaging 17beta-HSD10 dehydrogenase, an enzyme involved in Alzheimer's and Parkinson's diseases.

A luminescent sensor for tyrosine phosphorylation.

Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng.

C-H bond functionalization via hydride transfer: Lewis acid catalyzed alkylation reactions by direct intramolecular coupling of sp3 C-H bonds and reactive alkenyl oxocarbenium intermediates.

C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition.

Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.

C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers.

C-H bond functionalization via hydride transfer: direct coupling of unactivated alkynes and sp(3) C-H bonds catalyzed by platinum tetraiodide.

Development of pH-responsive fluorescent false neurotransmitters.

C-H bonds as ubiquitous functionality: a general approach to complex arylated imidazoles via regioselective sequential arylation of all three C-H bonds and regioselective N-alkylation enabled by SEM-group transposition.

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells.

Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: the activity measurement of 5α-steroid reductase in intact mammalian cells.

Intermolecular energy transfer from Tb3+ to Eu3+ in aqueous aggregates and on the surface of human cells.

C-H arylation of pyridines: high regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring.