Department of Chemistry
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Total synthesis of (-)-rhazinilam: asymmetric C[bond]H bond activation via the use of a chiral auxiliary.
Journal of the American Chemical Society Jun, 2002 | Pubmed ID: 12059212
Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains.
Journal of the American Chemical Society Aug, 2002 | Pubmed ID: 12175243
C-C bond formation via C-H bond activation: synthesis of the core of teleocidin B4.
Journal of the American Chemical Society Oct, 2002 | Pubmed ID: 12358522
C-C bond formation via C-H bond activation: catalytic arylation and alkenylation of alkane segments.
Journal of the American Chemical Society Nov, 2002 | Pubmed ID: 12418875
Pt(IV)-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation.
Organic letters Apr, 2003 | Pubmed ID: 12659572
Selective C-arylation of free (NH)-heteroarenes via catalytic C-H bond functionalization.
Journal of the American Chemical Society May, 2003 | Pubmed ID: 12720429
Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling.
Journal of the American Chemical Society Jul, 2003 | Pubmed ID: 12837082
Diversity synthesis via C-H bond functionalization: concept-guided development of new C-arylation methods for imidazoles.
Journal of the American Chemical Society Sep, 2003 | Pubmed ID: 12940740
Cobalt-catalyzed arylation of azole heteroarenes via direct C-H bond functionalization.
Organic letters Oct, 2003 | Pubmed ID: 14507184
Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation.
Organic letters Oct, 2003 | Pubmed ID: 14572247
Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec, 2003 | Pubmed ID: 14645418
Ru(III)-catalyzed cyclization of arene-alkene substrates via intramolecular electrophilic hydroarylation.
Organic letters Feb, 2004 | Pubmed ID: 14961628
New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases.
Journal of the American Chemical Society Mar, 2004 | Pubmed ID: 14982413
Cross-coupling of sp(3) C-H bonds and alkenes: catalytic cyclization of alkene-amide substrates.
Journal of the American Chemical Society Jun, 2004 | Pubmed ID: 15161275
Direct C-H bond arylation: selective palladium-catalyzed C2-arylation of N-substituted indoles.
Organic letters Aug, 2004 | Pubmed ID: 15330642
Oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization.
Journal of the American Chemical Society Oct, 2004 | Pubmed ID: 15479077
Two-photon induced uncaging of a reactive intermediate. Multiphoton in situ detection of a potentially valuable label for biological applications.
The Journal of organic chemistry Mar, 2005 | Pubmed ID: 15760198
Site-specific phenylation of pyridine catalyzed by phosphido-bridged ruthenium dimer complexes: a prototype for C-H arylation of electron-deficient heteroarenes.
Journal of the American Chemical Society Mar, 2005 | Pubmed ID: 15771470
Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B).
Journal of the American Chemical Society Apr, 2005 | Pubmed ID: 15796498
Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ.
Journal of the American Chemical Society Apr, 2005 | Pubmed ID: 15810815
Selective and catalytic arylation of N-phenylpyrrolidine: sp3 C-H bond functionalization in the absence of a directing group.
Journal of the American Chemical Society Apr, 2005 | Pubmed ID: 15826142
Direct palladium-catalyzed C-2 and C-3 arylation of indoles: a mechanistic rationale for regioselectivity.
Journal of the American Chemical Society Jun, 2005 | Pubmed ID: 15926829
A new fluorogenic transformation: development of an optical probe for coenzyme Q.
Organic letters Jun, 2005 | Pubmed ID: 15932212
Room temperature hydroalkylation of electron-deficient olefins: sp3 C-H functionalization via a lewis acid-catalyzed intramolecular redox event.
Journal of the American Chemical Society Sep, 2005 | Pubmed ID: 16131169
Room temperature intramolecular hydro-O-alkylation of aldehydes: sp3 C-H functionalization via a Lewis acid catalyzed tandem 1,5-hydride transfer/cyclization.
Organic letters Nov, 2005 | Pubmed ID: 16288523
Fluoromorphic substrates for fatty acid metabolism: highly sensitive probes for mammalian medium-chain acyl-CoA dehydrogenase.
Angewandte Chemie (International ed. in English) Jan, 2006 | Pubmed ID: 16365837
Selective and catalytic arylation of N-phenylpyrrolidine: (sp3) C-H bond functionalization in the absence of a directing group [J. Am. Chem. Soc. 2005, 127, 5284-5285].
Journal of the American Chemical Society Mar, 2006 | Pubmed ID: 16506792
Oxidative C-arylation of free (NH)-heterocycles via direct sp3 C-H bond functionalization [J. Am. Chem. Soc. 2004, 126, 13244-13246].
Journal of the American Chemical Society Mar, 2006 | Pubmed ID: 16506793
C-H bond functionalization in complex organic synthesis.
Science (New York, N.Y.) Apr, 2006 | Pubmed ID: 16601184
Catalytic C-H arylation of SEM-protected azoles with palladium complexes of NHCs and phosphines.
Organic letters May, 2006 | Pubmed ID: 16671761
Phosphorylation state-responsive lanthanide peptide conjugates: a luminescence switch based on reversible complex reorganization.
Organic letters Jun, 2006 | Pubmed ID: 16774241
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2006 | Pubmed ID: 16938874
Synthesis of luminescent heterometallic bis-lanthanide complexes via selective, sequential metallation.
Chemical communications (Cambridge, England) Oct, 2006 | Pubmed ID: 17024267
sp3 C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines.
Journal of the American Chemical Society Nov, 2006 | Pubmed ID: 17076471
Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles.
The Journal of organic chemistry Feb, 2007 | Pubmed ID: 17288392
Cocktails of Tb(3+) and Eu(3+) complexes: a general platform for the design of ratiometric optical probes.
Journal of the American Chemical Society Jun, 2007 | Pubmed ID: 17518468
Transposing molecular fluorescent switches into the near-IR: development of luminogenic reporter substrates for redox metabolism.
Journal of the American Chemical Society Jun, 2007 | Pubmed ID: 17542585
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.
Journal of the American Chemical Society Sep, 2007 | Pubmed ID: 17803274
Harnessing functional plasticity of enzymes: a fluorogenic probe for imaging 17beta-HSD10 dehydrogenase, an enzyme involved in Alzheimer's and Parkinson's diseases.
Journal of the American Chemical Society Nov, 2007 | Pubmed ID: 17958419
A luminescent sensor for tyrosine phosphorylation.
Organic letters Jan, 2008 | Pubmed ID: 18069839
Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng.
Journal of the American Chemical Society Oct, 2008 | Pubmed ID: 18826220
C-H bond functionalization via hydride transfer: Lewis acid catalyzed alkylation reactions by direct intramolecular coupling of sp3 C-H bonds and reactive alkenyl oxocarbenium intermediates.
Journal of the American Chemical Society Jan, 2009 | Pubmed ID: 19099474
C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition.
Journal of the American Chemical Society Mar, 2009 | Pubmed ID: 19206533
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.
Science (New York, N.Y.) Jun, 2009 | Pubmed ID: 19423778
C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers.
Organic letters Jul, 2009 | Pubmed ID: 19548698
C-H bond functionalization via hydride transfer: direct coupling of unactivated alkynes and sp(3) C-H bonds catalyzed by platinum tetraiodide.
Journal of the American Chemical Society Nov, 2009 | Pubmed ID: 19852462
Development of pH-responsive fluorescent false neurotransmitters.
Journal of the American Chemical Society Jul, 2010 | Pubmed ID: 20540519
C-H bonds as ubiquitous functionality: a general approach to complex arylated imidazoles via regioselective sequential arylation of all three C-H bonds and regioselective N-alkylation enabled by SEM-group transposition.
The Journal of organic chemistry Aug, 2010 | Pubmed ID: 20608749
(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells.
ACS chemical biology Dec, 2010 | Pubmed ID: 20836522
Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: the activity measurement of 5α-steroid reductase in intact mammalian cells.
ACS chemical biology Nov, 2010 | Pubmed ID: 20863068
Intermolecular energy transfer from Tb3+ to Eu3+ in aqueous aggregates and on the surface of human cells.
Organic letters Jun, 2011 | Pubmed ID: 21563789
C-H arylation of pyridines: high regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring.
Journal of the American Chemical Society Oct, 2011 | Pubmed ID: 21939181
Hui Zhang1,2,
Niko G. Gubernator3,4,
Minerva Yue1,
Roland G. W. Staal1,
Eugene V. Mosharov1,
Daniela Pereira1,
Vojtech Balsanek3,
Paul A. Vadola3,
Bipasha Mukherjee5,
Robert H. Edwards5,
David Sulzer1,2,6,
Dalibor Sames3
1Departments of Neurology, Columbia University,
2Departments of Psychiatry and Pharmacology, Columbia University,
3Department of Chemistry, Columbia University,
4, eMolecules, Inc.,
5Departments of Neurology and Physiology, University of California School of Medicine, San Francisco,
6Division of Molecular Therapeutics, New York Psychiatric Institute
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