Multidisciplinary Neuroprotection Laboratories,
Department of Anesthesiology,
Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology
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Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.
American journal of physiology. Heart and circulatory physiology May, 2002 | Pubmed ID: 11959653
Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.
Neurological research Jul, 2002 | Pubmed ID: 12117325
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.
Stroke; a journal of cerebral circulation Sep, 2002 | Pubmed ID: 12215605
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.
Free radical biology & medicine Oct, 2002 | Pubmed ID: 12361805
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
Free radical biology & medicine Oct, 2002 | Pubmed ID: 12374626
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation Dec, 2002 | Pubmed ID: 12468796
Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.
Free radical biology & medicine Dec, 2002 | Pubmed ID: 12488134
Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation Feb, 2003 | Pubmed ID: 12574555
Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.
Drug news & perspectives Dec, 2002 | Pubmed ID: 12677251
Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.
Anesthesiology Nov, 2003 | Pubmed ID: 14576552
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.
Anesthesiology May, 2004 | Pubmed ID: 15114213
A no-laminectomy spinal cord compression injury model in mice.
Journal of neurotrauma May, 2004 | Pubmed ID: 15165367
Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy.
Neuroscience letters Aug, 2004 | Pubmed ID: 15276251
Oxidants, antioxidants and the ischemic brain.
The Journal of experimental biology Aug, 2004 | Pubmed ID: 15299043
Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.
Anesthesia and analgesia Sep, 2004 | Pubmed ID: 15333428
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.
European journal of pharmacology Feb, 2006 | Pubmed ID: 16455070
A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.
Brain research Feb, 2006 | Pubmed ID: 16458861
A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.
Neurocritical care , 2006 | Pubmed ID: 16498192
Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.
Anesthesiology Jul, 2006 | Pubmed ID: 16809998
Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.
Neurocritical care , 2006 | Pubmed ID: 16960300
Isoflurane provides long-term protection against focal cerebral ischemia in the rat.
Anesthesiology Jan, 2007 | Pubmed ID: 17197850
Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.
AJR. American journal of roentgenology Apr, 2007 | Pubmed ID: 17377054
Transient global cerebral ischemia induces a massive increase in protein sumoylation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2008 | Pubmed ID: 17565359
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2008 | Pubmed ID: 18167501
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?
Journal of neurochemistry Aug, 2008 | Pubmed ID: 18410505
Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.
Experimental neurology Oct, 2008 | Pubmed ID: 18625221
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.
Free radical biology & medicine Oct, 2009 | Pubmed ID: 19631268
Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.
Journal of neurosurgical anesthesiology Oct, 2009 | Pubmed ID: 19955895
Development of a simplified spinal cord ischemia model in mice.
Journal of neuroscience methods Jun, 2010 | Pubmed ID: 20394775
Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass.
Anesthesia and analgesia Jul, 2010 | Pubmed ID: 20519424
Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage.
Stroke; a journal of cerebral circulation Feb, 2011 | Pubmed ID: 21193749
The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery Aug, 2011 | Pubmed ID: 21277590
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
Dalton transactions (Cambridge, England : 2003) Apr, 2011 | Pubmed ID: 21384047
Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.
The Journal of pharmacology and experimental therapeutics Sep, 2011 | Pubmed ID: 21652782
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Journal of proteome research Feb, 2012 | Pubmed ID: 22082260
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.
Free radical biology & medicine May, 2012 | Pubmed ID: 22336516
Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat.
Journal of cardiothoracic and vascular anesthesia Feb, 2013 | Pubmed ID: 22841525
Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre , 2013 | Pubmed ID: 23075911
Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.
Anesthesiology Dec, 2012 | Pubmed ID: 23143806
Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.
Free radical biology & medicine May, 2013 | Pubmed ID: 23328731
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
Nature May, 2013 | Pubmed ID: 23615612
Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.
Inorganic chemistry May, 2013 | Pubmed ID: 23646875
Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.
Antioxidants & redox signaling May, 2014 | Pubmed ID: 23706004
Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2014 | Pubmed ID: 24301296
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
Stroke; a journal of cerebral circulation Apr, 2014 | Pubmed ID: 24569813
ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.
Journal of neuroscience research Jul, 2014 | Pubmed ID: 24633884
Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.
Journal of psychiatry & neuroscience : JPN Jul, 2014 | Pubmed ID: 24690371
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2001 | Pubmed ID: 11425886
A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat.
Journal of neuroscience methods Feb, 2015 | Pubmed ID: 25526908
Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jun, 2015 | Pubmed ID: 25712497
CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery.
Neuroscience letters Jun, 2015 | Pubmed ID: 25881484
Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.
International journal of radiation oncology, biology, physics Nov, 2015 | Pubmed ID: 26530759
O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2016 | Pubmed ID: 26661187
Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Dec, 2016 | Pubmed ID: 26661238
Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.
Neurocritical care Oct, 2016 | Pubmed ID: 26896093
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2017 | Pubmed ID: 27217380
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.
The Journal of clinical investigation Aug, 2016 | Pubmed ID: 27400126
Anesthesia in Experimental Stroke Research.
Translational stroke research Oct, 2016 | Pubmed ID: 27534542
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.
Neuroscience Feb, 2017 | Pubmed ID: 27919694
Anesthetic Neuroprotection? It's Complicated.
Anesthesiology Apr, 2017 | Pubmed ID: 28182586
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
Stroke Jun, 2017 | Pubmed ID: 28487326
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2017 | Pubmed ID: 28505619
Targeting the SUMO pathway for neuroprotection in brain ischaemia.
Stroke and vascular neurology Sep, 2016 | Pubmed ID: 28959470
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.
Aging and disease Feb, 2018 | Pubmed ID: 29392079
Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.
Laboratory investigation; a journal of technical methods and pathology Jun, 2018 | Pubmed ID: 29472640
Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy.
The Journal of infectious diseases Aug, 2018 | Pubmed ID: 29788431
High-speed widefield photoacoustic microscopy of small-animal hemodynamics.
Biomedical optics express Oct, 2018 | Pubmed ID: 30319896
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.
Journal of the American Heart Association 09, 2018 | Pubmed ID: 30371162
Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice.
Journal of biomechanical engineering Dec, 2019 | Pubmed ID: 31596925
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.
Experimental neurology Apr, 2020 | Pubmed ID: 31962128
PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.
Stroke May, 2020 | Pubmed ID: 32212900
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism May, 2021 | Pubmed ID: 32787543
MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.
Journal of neuroinflammation Aug, 2020 | Pubmed ID: 32867797
Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2020 | Pubmed ID: 32910521
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
Experimental neurology May, 2021 | Pubmed ID: 33600817
Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.
Journal of the American Heart Association Jun, 2021 | Pubmed ID: 34013738
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.
Journal of the American Heart Association Jun, 2021 | Pubmed ID: 34111943
Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.
Shock (Augusta, Ga.) Nov, 2021 | Pubmed ID: 34652341
Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.
Neuromodulation : journal of the International Neuromodulation Society Apr, 2022 | Pubmed ID: 35131154
Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice.
Brain research bulletin Jun, 2022 | Pubmed ID: 35304288
Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice.
Oxidative medicine and cellular longevity , 2022 | Pubmed ID: 35391930
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.
Journal of neuroinflammation Apr, 2022 | Pubmed ID: 35392936
Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics.
Molecules (Basel, Switzerland) Jul, 2022 | Pubmed ID: 35807529
Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.
Biology Jun, 2022 | Pubmed ID: 36101338
SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.
Neurocritical care Oct, 2022 | Pubmed ID: 36224490
Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.
Frontiers in cellular neuroscience , 2022 | Pubmed ID: 36313623
A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.
Science immunology Mar, 2023 | Pubmed ID: 36930731
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