Huaxin Sheng

Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.

Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.

Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.

Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.

A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.

Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage.

Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury.

Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.

Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.

A no-laminectomy spinal cord compression injury model in mice.

Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy.

Oxidants, antioxidants and the ischemic brain.

Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.

Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.

A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.

Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.

Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.

Isoflurane provides long-term protection against focal cerebral ischemia in the rat.

Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.

Transient global cerebral ischemia induces a massive increase in protein sumoylation.

Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.

Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?

Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Development of a simplified spinal cord ischemia model in mice.

Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass.

Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage.

The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass.

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.

Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage.

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat.

Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.

Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.

Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.

Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.

Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.

ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.

Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.

Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.

A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat.

Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.

CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery.

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.

Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat.

Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.

Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.

Anesthesia in Experimental Stroke Research.

Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.

Anesthetic Neuroprotection? It's Complicated.

XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.

Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.

Targeting the SUMO pathway for neuroprotection in brain ischaemia.

Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.

Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.

Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy.

High-speed widefield photoacoustic microscopy of small-animal hemodynamics.

Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.

Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice.

Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.

PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.

Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.

MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.

Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.

Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.

Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.

Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.

Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.

Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice.

Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice.

Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.

Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics.

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.

SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats.

Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.

A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.