Department of Translational Oncology
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Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19110638
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation Apr, 2009 | Pubmed ID: 19307726
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.
Science (New York, N.Y.) Nov, 2009 | Pubmed ID: 19892975
Comprehensive genomic access to vector integration in clinical gene therapy.
Nature medicine Dec, 2009 | Pubmed ID: 19966782
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing.
Nature protocols Aug, 2010 | Pubmed ID: 20671722
Lentiviral vector integration profiles differ in rodent postmitotic tissues.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2011 | Pubmed ID: 21364536
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.
Hepatology (Baltimore, Md.) May, 2011 | Pubmed ID: 21520180
Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.
Molecular therapy : the journal of the American Society of Gene Therapy Jul, 2011 | Pubmed ID: 21540837
An unbiased genome-wide analysis of zinc-finger nuclease specificity.
Nature biotechnology Sep, 2011 | Pubmed ID: 21822255
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2011 | Pubmed ID: 21862999
Retroviral gene therapy for X-linked chronic granulomatous disease: results from phase I/II trial.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2011 | Pubmed ID: 21878903
Analyzing the number of common integration sites of viral vectors--new methods and computer programs.
PloS one , 2011 | Pubmed ID: 22022353
Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy.
Methods in enzymology , 2012 | Pubmed ID: 22365775
Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22367877
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2013 | Pubmed ID: 22371846
Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.
Human gene therapy methods Apr, 2012 | Pubmed ID: 22559057
Dissecting the genomic complexity underlying medulloblastoma.
Nature Aug, 2012 | Pubmed ID: 22832583
Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector.
Experimental hematology Jan, 2013 | Pubmed ID: 22989760
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.
Nature methods Feb, 2013 | Pubmed ID: 23314173
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.
Cancer cell Feb, 2013 | Pubmed ID: 23410972
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
Nature genetics Aug, 2013 | Pubmed ID: 23817572
Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2014 | Pubmed ID: 23941813
Transgenic Expression of Human Glial Cell Line-Derived Neurotrophic Factor from Integration-Deficient Lentiviral Vectors is Neuroprotective in a Rodent Model of Parkinson's Disease.
Human gene therapy Apr, 2014 | Pubmed ID: 24635742
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
Cancer cell Mar, 2014 | Pubmed ID: 24651015
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Nature May, 2014 | Pubmed ID: 24847876
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