Cynthia C Bartholomae

Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples.

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy.

Comprehensive genomic access to vector integration in clinical gene therapy.

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing.

Lentiviral vector integration profiles differ in rodent postmitotic tissues.

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk.

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

An unbiased genome-wide analysis of zinc-finger nuclease specificity.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Retroviral gene therapy for X-linked chronic granulomatous disease: results from phase I/II trial.

Analyzing the number of common integration sites of viral vectors--new methods and computer programs.

Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy.

Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing.

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.

Dissecting the genomic complexity underlying medulloblastoma.

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector.

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer.

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice.

Transgenic Expression of Human Glial Cell Line-Derived Neurotrophic Factor from Integration-Deficient Lentiviral Vectors is Neuroprotective in a Rodent Model of Parkinson's Disease.

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.